Evidence map›Paper›PMID 41004484›Full record

Observational studyPloS one2025

The specificity for the correlation between viscera and somato in chronic stable angina pectoris patients and healthy controls: An assessor-blinded and comparative trial.

Yongliang Jiang, Xiaoyu Li, Xiaofen He, Hantong Hu, Yajun Zhang, Xiaomei Shao, Jianqiao Fang

Registry-linked trialAbstract readComparative StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04046640 (A Study on the Heat Transport Characteristics of Meridian Phenomenon for the Heart and Lung Meridians Based on Patients With Stable Angina Pectoris), which is not on this map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04046640 unknown statusnot on this map

A Study on the Heat Transport Characteristics of Meridian Phenomenon for the Heart and Lung Meridians Based on Patients With Stable Angina Pectoris

TypeobservationalSponsorZhejiang Chinese Medical UniversityRan2020 to 2021Enrolled80ConditionsChronic Obstructive Pulmonary DiseaseArmsInfrared thermal imaging
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yongliang JiangDepartment of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, China.
Xiaoyu LiDepartment of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, China.
Xiaofen HeDepartment of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, China.
Hantong HuDepartment of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, China.
Yajun ZhangDepartment of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, China.
Xiaomei ShaoDepartment of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, China.
Jianqiao FangDepartment of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou City, China.ORCID https://orcid.org/0009-0002-7992-9578

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlthough the relationship between viscera and somato remains unclear, a deeper comprehension of the relationship will maximize the diagnostic and therapeutic benefits. Therefore, this study was conducted to explore the specificity of visceral-somatic associations in the pathological state of chronic stable angina pectoris (CSAP).

methods40 individuals with CSAP participated in the study, while 40 individuals in the healthy control group were age-matched healthy individuals. Four distinct somatic locations dispersed along the heart and lung meridians were subjected to laser doppler flowmetry, infrared thermography, and functional near-infrared spectroscopy in order to assess (1) perfusion unit (PU), (2) temperature, and (3) regional oxygen saturation (rSO2). These three outcomes represented the somatic sites' microcirculatory, thermal, and metabolic properties.

resultsRegarding the microcirculatory characteristics, PU at the somatic sites of the heart meridian (Shenmen(HT7)/Shaohai(HT3)) in the CSAP group substantially increased (P < 0.05) compared to the healthy control group, while there was no statistically significant difference in PU at the somatic sites of the lung meridian between the two groups. Regarding the thermal characteristics, compared with the healthy control group, the temperature of the somatic sites of the heart meridian (Shenmen(HT7)/Shaohai(HT3)), as well as Taiyuan (LU9) of the lung meridian, increased significantly (P < 0.05). With regard to the metabolic features, rSO2 of the somatic site of the heart meridian (Shaohai (HT3)) in the CSAP group decreased significantly (P < 0.05) as compared to the healthy control group. The between-group difference in rSO2 in the lung and heart meridians (Taiyuan (LU9)/Chize (LU5)) and Shenmen (HT7), respectively, was not statistically significant.

conclusionsSpecific somatic sites in the heart meridian typically exhibit more significant changes in their microcirculatory, thermal, and metabolic characteristics than those in the lung meridian, thereby supporting the relative specificity for the visceral-somatic association in the disease state of CSAP. Trial registration: Clinicaltrials.gov (registration number: NCT04046640).

Indexed as

Angina, StableVisceraAgedCase-Control StudiesChronic DiseaseFemaleHumansLaser-Doppler FlowmetryLungMaleMeridiansMicrocirculationMiddle AgedSpectroscopy, Near-Infrared

Identifiers

PMID41004484
PMCPMC12469238

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.