ArticlePloS one2025
Differential involvement of feedback and feedforward control networks across disfluency types in adults who stutter: Evidence from resting state functional connectivity.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis study investigated the relationship between different disfluency types (i.e., repetitions, prolongations, and blocks) and resting state functional connectivity in the feedback (FB) and feedforward (FF) control networks in 20 adults who stutter.
methodsFrequency of each disfluency type was coded in speech samples derived from the Stuttering Severity Instrument, and functional connectivity between brain regions of interest was derived from resting state functional magnetic resonance imaging scans. We used LASSO regressions to identify the connections that most strongly predicted each disfluency type.
resultsBoth repetitions and prolongations were significantly associated with increased connectivity in left ventral motor cortex - right ventral premotor cortex, which is hypothesized to be involved in FB control of speech. In contrast, blocks were significantly associated with reduced connectivity in right anterior cerebellum - left ventral lateral thalamic nucleus and increased connectivity in left presupplementary motor area - left posterior inferior frontal sulcus, both of which are hypothesized to be involved in FF control of speech.
conclusionOur findings suggest that repetitions and prolongations may be associated with increased reliance on FB-based corrective mechanisms, whereas blocks may be associated with disrupted FF-based initiation mechanisms. These neural underpinnings may correspond to different challenges in terminating or initiating motor commands and underscore the nuanced neurobiological processes underlying speech disfluencies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.