Evidence map›Paper›PMID 41004400›Full record

ArticleJournal of neuromuscular diseases2026

Atypical features including acquired oculomotor apraxia in

Nathan Hostetler, Sydney Zakutney, Catherine Elizabeth Pringle, Jocelyn Zwicker, Ari Breiner

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuromuscular diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nathan HostetlerThe Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.ORCID 0000-0003-0120-9941
Sydney ZakutneyThe Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Catherine Elizabeth PringleDivision of Neurology, Department of Medicine, The Ottawa Hospital, Ottawa, Ontario, Canada.
Jocelyn ZwickerThe Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
Ari BreinerThe Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe phenotypic variability of

objectivesDescribe a family with

methodsChart review.

resultsA 52-year-old male experiencing 4 months of progressive right lower leg spasticity with a family history of FTD was referred to us. Within 15 months, he was anarthric and required a powered wheelchair. He developed acquired ocular motor apraxia, consistent with supranuclear ophthalmoplegia. He later developed laryngeal dystonia which led to his death. Ten years later, his 67-year-old brother presented with 8 months of progressive spastic dysarthria, hyperreflexia, right foot drop, and right facial weakness. Genetic testing revealed heterozygous

conclusionsThis family's presentation expands on sparse reports of

Indexed as

ApraxiasC9orf72 ProteinMotor Neuron DiseaseAgedAmyotrophic Lateral SclerosisFrontotemporal DementiaHumansMaleMiddle AgedMutationPedigreePhenotypeC9orf72 ProteinC9orf72 protein, humanamyotrophic lateral sclerosisapraxiaataxiamotor neuron diseaseneuromuscular diseaseneuromuscular manifestationsophthalmoplegiaparalysisprimary lateral sclerosisTDP-43 proteinopathies

Identifiers

PMID41004400
PMCPMC13434936

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.