Evidence map›Paper›PMID 41004282›Full record

ArticleEuropean stroke journal2025

The clinical association of left atrial appendage thrombus on CTA with functional outcome.

Joel Winders, Angelo Di Bartolo, Jamin Kim, Duncan Wilson, Sajith Senadeera, Yassar Alamri, John Fink, James Beharry, Mark W Parsons, Christopher Levi and 12 more

Abstract read
In one paragraph

Article in European stroke journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Joel WindersDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.
Angelo Di BartoloDepartment of Radiology, Christchurch Hospital, Christchurch, New Zealand.
Jamin KimDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.ORCID 0009-0005-5556-1109
Duncan WilsonNew Zealand Brain Research Institute, Christchurch, New Zealand.
Sajith SenadeeraDepartment of Radiology, Christchurch Hospital, Christchurch, New Zealand.
Yassar AlamriDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.
John FinkDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.
James BeharryDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.
Mark W ParsonsDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
Christopher LeviDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
Neil SprattDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
Beng Lim Alvin ChewDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
Md Golam HasnainFaculty of Medicine, University of Newcastle, Callaghan, NSW, Australia.
Ferdinand MiteffDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
Leon RinkelDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0002-0291-8515
Shan Sui NioDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.ORCID 0000-0003-3401-7014
Sinan Al-HadethiDepartment of Radiology, John Hunter Hospital, Newcastle, NSW, Australia.
Anthony LimDepartment of Radiology, Christchurch Hospital, Christchurch, New Zealand.ORCID 0000-0001-6694-5398
Jonathan CoutinhoDepartment of Neurology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Carlos Garcia-EsperonDepartment of Neurology, John Hunter Hospital, Newcastle, NSW, Australia.
Teddy Y WuDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.ORCID 0000-0003-1845-1769
Alexander Berry-NoronhaDepartment of Neurology, Christchurch Hospital, Christchurch, New Zealand.ORCID 0000-0003-4189-5157

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLeft atrial appendage (LAA) thrombus is associated with atrial fibrillation (AF) and can be a marker of atrial cardiomyopathy. We determined the association between computed tomography angiography (CTA) identified LAA thrombus in patients presenting with acute ischaemic stroke or transient ischaemic attack (TIA), and 3-month outcome.

methodsWe undertook a dual-centre, retrospective cohort study from New Zealand and Australia. All consecutive patients presenting with acute ischaemic stroke or TIA during the inclusion period who underwent acute stroke imaging were included. We analysed the association with CTA-LAA thrombus and 3-month outcome on modified Rankin Scale using multivariable logistic regression models adjusted for known predictors of outcome.

resultsOf the 1435 patients included, 1304 (90.9%) had acute ischaemic stroke and 131 (9.1%) had TIA. 582 (41%) had confirmed intracranial medium or large vessel occlusion (MLVO), and 565 (40%) received reperfusion therapies. CTA-LAA thrombus was identified in 58 (4.0%) patients, and these patients were older (median age 85 (IQR 75-88) vs 73 (63-81),

conclusionsCTA-LAA thrombus detected during the acute stroke imaging protocol in patients with ischemic stroke or TIA is a predictor of worse outcome.

Indexed as

atrial fibrillationleft atrial appendage thrombusStroke

Identifiers

PMID41004282
PMCPMC12474567

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.