Evidence map›Paper›PMID 41004227›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

Versatile

Rensen Ran, Lanxin Li, Peng Chen, Shuai Li, Peng Wang, Zhenpeng Zhu, Xiran Wang, Yonglong Chen, Jing Hang, Weizheng Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Current issues in molecular biology · 2026
    Review
  2. Article
  3. Tyrosinase-Deficient Skin Melanophore Lineage inInternational journal of molecular sciences · 2026
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rensen Ran *State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.ORCID 0009-0001-9863-4735
Lanxin Li *Department of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.
Peng ChenDepartment of Neurosurgery, The second affiliated hospital of Xi'an Medical University, Xi'an 710038, China.
Shuai LiInnovation Center of Cardiometabolic Diseases, Guangdong Medical University, Dongguan 523822, China.ORCID 0000-0002-7870-7781
Peng WangDepartment of Surgery, Hebei North University, Zhangjiakou, Hebei 075000, China.ORCID 0009-0002-1009-6416
Zhenpeng ZhuDepartment of Surgery, Hebei North University, Zhangjiakou, Hebei 075000, China.
Xiran WangDepartment of Bioinformatics, School of Health Care, Changchun Vocational College of Health, Changchun, Jilin 130000, China.
Yonglong ChenDepartment of Biology, School of Life Sciences, Southern University of Science and Technology, Shenzhen 518055, China.ORCID 0000-0002-4933-113X
Jing HangState Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.ORCID 0000-0002-0334-6467
Weizheng LiangHebei Key Laboratory of Systems Biology and Gene Regulation, Central Laboratory, The First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China.ORCID 0000-0002-7274-6034

Funding

Key Clinical Projects of Peking University Third Hospital BYSYZD2023033National Key Research & Development Program of China 2023YFC2705902National Natural Science Foundation of China 32470880Natural science project of Hebei North University No.XJ2024035Peking University Medicine Sailing Program for Young Scholars& Scientific & Technological Innovation BMU2025YFJHPY035Shenzhen Science and Technology Program JCYJ20210324120205015Zhangjiakou City Key R&D Plan Project No.2322088D
6 · The paper itself

Abstract

Targeting exogenous gene integrations in animals often exhibits low efficiency, limiting the development of gene knock-in models. Theoretically, by screening founder generation individuals based on the cell phenotypes resulting from gene knock-ins and leveraging the high fecundity of animals, heritable descendants with targeted knock-ins can be efficiently generated. Therefore, we utilized the high fecundity of

Indexed as

Proto-Oncogene Proteins B-rafXenopusAnimalsAnimals, Genetically ModifiedGene Knock-In TechniquesHumansMelanocytesMicrophthalmia-Associated Transcription FactorRetinaBRAF protein, humanMicrophthalmia-Associated Transcription FactorProto-Oncogene Proteins B-rafBRAFV600E knock-inmelanocytic and xanthocytic neviretinal regenerationxanthophoromaX. tropicalis

Identifiers

PMID41004227
PMCPMC12501161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.