Evidence map›Paper›PMID 41004107›Full record

ReviewAdvances in neurobiology2025

Neuroprotective and Neurotrophic Effects of Astaxanthin on the Brain.

Jang Soo Yook, Hideaki Soya

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jang Soo YookDivision of Humanities and Social Sciences, Pohang University of Science and Technology (POSTECH), Pohang, Gyeongsangbuk-do, South Korea. yookjs@postech.ac.kr.
Hideaki SoyaLaboratory of Exercise Biochemistry and Neuroendocrinology, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative stress in the brain is associated with the development and progression of neurological disorders, posing antioxidant nutrients as an effective strategy for protecting neuronal cells and potentially slowing cognitive decline. Bioactive compounds from natural sources with antioxidant effects promote brain health. Among various natural compounds, astaxanthin (ASX), a potent red-pigment carotenoid found in various microorganisms and marine animals, is well recognized for its potential health benefits. In this review, we highlight the promising neuroprotective effects of ASX through cellular experiments and animal models. This review can provide novel insights on the therapeutic potential of ASX through its antioxidant, anti-inflammatory, and anti-apoptotic effects against neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. In addition to demonstrating the neurotrophic effects of ASX on structural and functional changes in hippocampal neuronal plasticity, this review also discusses its synergistic potential with other interventions, such as exercise.

Indexed as

AntioxidantsBrainNeurodegenerative DiseasesNeuroprotective AgentsAnimalsHumansOxidative StressXanthophyllsAntioxidantsastaxanthineNeuroprotective AgentsXanthophyllsAdult hippocampal neurogenesisAntioxidantAstaxanthinExerciseNeuroprotection

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.