Evidence map›Paper›PMID 41004104›Full record

ReviewAdvances in neurobiology2025

Assessing Exercise and Fitness-Related Brain Health Using Multi-modal Magnetic Resonance Imaging Outcomes.

J Carson Smith, Daniel D Callow, Gabriel S Pena, Jeremy J Purcell

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J Carson SmithUniversity of Maryland, College Park, MD, USA. carson@umd.edu.
Daniel D CallowUniversity of Maryland, College Park, MD, USA.
Gabriel S PenaUniversity of Maryland, College Park, MD, USA.
Jeremy J PurcellUniversity of Maryland, College Park, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several magnetic resonance imaging (MRI)-based modalities have provided insight into how acute and chronic exercise and physical activity impact brain health. Structural MRI-based measures provide information regarding brain volume and cortical thickness, diffusion-weighted imaging measures provide indices of white matter and gray microstructure, and cerebrovascular effects that may be assessed through measures of regional cerebral blood flow, and brain activation and neural networks can be indexed using task-based and connectivity-based functional MRI, respectively. In this chapter, a series of studies are described in which these multi-modal MRI outcomes, along with indices of neurocognitive function, have been documented after a brief walking exercise intervention in healthy older adults and those diagnosed with mild cognitive impairment. Finally, we provide some additional insight into the neurophysiological mechanisms that may be foundational for these effects, but are yet not measurable in humans. Multi-modal neuroimaging is a non-invasive method in humans to assess the potential mechanisms whereby acute and chronic exercise may exert benefits to brain function and neural networks related to cognition that may protect older adults from age-related cognitive decline and dementia.

Indexed as

BrainExerciseMagnetic Resonance ImagingMultimodal ImagingNeuroimagingPhysical FitnessCognitive DysfunctionHumansAlzheimer’s DiseaseCognitionExerciseMagnetic resonance imagingMild cognitive impairmentPhysical activity

Identifiers

PMID41004104

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.