Evidence map›Paper›PMID 41004096›Full record

ReviewAdvances in neurobiology2025

Pupil Dynamics Predict Exercise Brain Stimulation: An Overview of Exercise Pupillometry.

Ryuta Kuwamizu, Yudai Yamazaki, Kazuya Suwabe, Kenji Suzuki, Yoshiyuki Sankai, Hideaki Soya

Abstract readReview
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In one paragraph

Review in Advances in neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ryuta KuwamizuSport Neuroscience Division, Kokoro Division, Advanced Research Initiative for Human High Performance (ARIHHP), Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan. kuwamizu.ryuta.ft@u.tsukuba.ac.jp.
Yudai YamazakiLaboratory of Exercise Biochemistry and Neuroendocrinology, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Kazuya SuwabeLaboratory of Exercise Biochemistry and Neuroendocrinology, Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Kenji SuzukiCenter for Cybernics Research, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Yoshiyuki SankaiCenter for Cybernics Research, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Hideaki SoyaSport Neuroscience Division, Kokoro Division, Advanced Research Initiative for Human High Performance (ARIHHP), Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Proper physical activity, even at a very light intensity such as walking or slow running, improves brain health related to prefrontal executive function and hippocampal memory. However, the neural mechanism behind the cognitive enhancement that occurs during dynamic aerobic exercise is elusive and remains unclear in humans. Recently, pupillometry has been attracting attention as a kind of readout of the brain's ascending arousal mechanism, especially for brain noradrenergic and cholinergic system activation. Thus, to identify the neural mechanism behind the effects of very-light-intensity exercise, our recent work has focused on pupillometry during aerobic exercise, and we have successfully shown the efficacy of pupil dilation as a biological marker, even during very-light-/light-intensity exercise (below the ventilatory threshold). Interestingly, neuromelanin-MRI contrast in the LC, a marker of LC integrity, predicted the magnitude of exercise-induced pupil dilation and psychological arousal changes at the individual level. In addition, we have found that pupil dilation during exercise predicted the positive impact of acute very-light-/light-intensity exercise on prefrontal executive performance and hippocampal memory performance. The series of exercise pupillometry studies we will discuss here provides essential insights into the neural substrates of the advantages of exercise-induced brain stimulation in humans.

Indexed as

BrainExercisePupilArousalExecutive FunctionHumansArousalCatecholamineExecutive functionEye trackingMemoryPupil diameter

Identifiers

PMID41004096

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.