Evidence map›Paper›PMID 41004086›Full record

ReviewAdvances in experimental medicine and biology2025

Entosis in Health and Disease.

Jyotirekha Das, Michael Overholtzer

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in experimental medicine and biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Jyotirekha DasCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Michael OverholtzerCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. overhom1@mskcc.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Entosis is a mechanism of cell-in-cell formation that resembles phagocytosis but is regulated by distinct processes related to cell-cell adhesion and actomyosin tension. Entosis results in the engulfment of cells with high levels of tension, which become internalized into cells with lower tension, following the formation of adherens junctions between the pair. The resulting "cell-in-cell" structures typically resolve in a manner that leads to the death of the internalized cells, although other fates, including internalized cell release, are also possible. Entosis is induced in response to a variety of stressors, sometimes in parallel to other forms of cell death, and has been observed to occur in cancer as well as normal tissues. Here we discuss the mechanism of entosis and consider its unique properties compared to other forms of cell death and engulfment.

Indexed as

EntosisNeoplasmsActomyosinAdherens JunctionsAnimalsCell AdhesionCell DeathHumansPhagocytosisActomyosinAdherens junctionsAutophagyE-cadherinEntosisEntotic cell deathLysosomeRhoROCK

Identifiers

PMID41004086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.