Evidence map›Paper›PMID 41004007›Full record

ReviewSub-cellular biochemistry2025

Heterogeneity of Molecular Crowding and Liquid-Liquid Phase Separation.

Mitsuki Tsuruta, Sumit Shil, Keiko Kawauchi, Daisuke Miyoshi

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mitsuki TsurutaFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, Hyogo, Japan.
Sumit ShilFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, Hyogo, Japan.
Keiko KawauchiFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, Hyogo, Japan.
Daisuke MiyoshiFaculty of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, Kobe, Hyogo, Japan. miyoshi@konan-u.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The inside of a living cell is highly crowded with extremely diverse biomacromolecules, small metabolites and osmolytes. The molecular conditions in cells change dynamically and rapidly depending on the cell cycle and state, organelle, and compartment. Much remains unknown regarding how biomolecular interactions and reactions can proceed in a spatiotemporally specific manner in such crowded, heterogeneous, and dynamic molecular environments. Selective condensation/droplet formation of biomolecules via liquid-liquid phase separation may be critical for interactions and reactions inside cells. In this chapter, we briefly describe the heterogeneity of molecular environments inside cells and the biological roles of liquid-liquid phase separation that allows biomolecular interactions and reactions in such heterogenous molecular environments. Finally, we discuss the mutual relationship between molecular crowding and liquid-liquid phase separation.

Indexed as

Liquid-Liquid ExtractionAnimalsHumansPhase SeparationIntrinsic disorder proteinLiquid-liquid phase separationMolecular crowdingNeurodegenerative diseaseWeak interaction

Identifiers

PMID41004007

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.