ReviewSub-cellular biochemistry2025
Molecular Crowing in Nuclear Pore.
Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Calorie restriction and exercise differentially regulate AMP-activated protein kinase across subcellular compartments in skeletal muscle from older male rats.Experimental gerontology · 2026Article
- Phosphoproteomic Landscape of HDLBP: Insights into Function and Disease Associations.International journal of molecular sciences · 2026Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear pores serve as the sole gates mediating nucleocytoplasmic molecular communication. They constantly accept heavy molecular traffic at a rate of ~1000 molecules per second, selected from a vast number of molecules randomly approaching the pores. The central channel of the pores are highly crowded with an intrinsically disordered region of pore-forming subunits and this channel functions as a selective permeability barrier. Recently, the phase separation properties of the hydrophobic subunits of pores have been reported, together with the flexible amphiphilic nature of the transporting molecules. These findings suggest that phase separation is a fundamental mechanism of action in nuclear pores. In this chapter, the entire nucleocytoplasmic transport system and composition of the nuclear pore complex are reviewed, followed by a detailed review of recent studies focusing on the characteristic features of both nuclear pores and transporting molecules. Finally, intrinsic and extrinsic factors that adaptively affect the function of the molecular crowding barrier are introduced.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.