Evidence map›Paper›PMID 41003996›Full record

ReviewSub-cellular biochemistry2025

Role of Aqueous Media in Macromolecular Crowding.

Pedro P Madeira, Vladimir N Uversky, Boris Y Zaslavsky

Abstract readReview
PubMed Publisher
In one paragraph

Review in Sub-cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Pedro P MadeiraI3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal.
Vladimir N UverskyDepartment of Molecular Medicine and Byrd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. vuversky@usf.edu.
Boris Y ZaslavskyCleveland Diagnostics, Cleveland, OH, USA. boris.zaslavsky@clevelanddx.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The behavior of biomolecules in a crowded environment is affected by a number of factors, with the excluded volume being traditionally considered as a major contributor to the macromolecular crowding effects in polymer solutions. In addition to the hard nonspecific steric interactions representing the excluded volume effects, other commonly considered factors are the so-called soft interactions between the crowder and the crowdee, such as electrostatic, hydrophobic, and van der Waals interactions. However, the changes in the solvent properties of aqueous media induced by the crowding agents may represent important but commonly neglected factor affecting behavior of biomolecules in a crowded environment. This chapter systematically represents information in support to this hypothesis. Presented data clearly show that the crowding agents do induce changes in solvent properties of aqueous media in crowded environment. Therefore, these changes should be taken into account for crowding effect analysis.

Indexed as

Macromolecular SubstancesWaterHydrophobic and Hydrophilic InteractionsSolventsStatic ElectricityMacromolecular SubstancesSolventsWaterAnd hydrogen-bond acceptor basicityAqueous two-phase systemsDipolarity/polarizabilityHydrogen-bond donor acidityMacromolecular crowdingSolvatochromic dyesSolvent properties of aqueous media

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.