ArticleInflammopharmacology2025
In vitro antioxidant activity and in vivo antinociceptive and anti-inflammatory effects of the hydroethanolic extract from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg in Swiss mice.
Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Chemical characterization and antinociceptive and anti-inflammatory activities of the aqueous extract of Myrciaria floribunda (H. West ex Willd.) O. Berg fruit peel.Inflammopharmacology · 2026Article
- Insecticidal Activity of Essential Oil from the Leaves ofPlants (Basel, Switzerland) · 2026Article
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Authors and funding
11 authors.
Funding
Abstract
Myrciaria floribunda (H. West ex Willd.) O. Berg, a native species of the Myrtaceae family, is traditionally used in folk medicine and is known for its anticholinesterase, antioxidant, and antitumor properties. Despite this, its analgesic and anti-inflammatory effects remain underexplored. This study aimed to investigate the in vitro antioxidant and in vivo antinociceptive and anti-inflammatory activities of the hydroethanolic extract from M. floribunda leaves (MfHE). MfHE was prepared and analyzed by HPLC-DAD-MS, revealing 25 compounds, mainly tannins and flavonoids. Quantification showed 403.09 mg GAE/g of total phenolics and 2.94 mg QE/g of flavonoids. Antioxidant potential was evaluated using the DPPH assay (IC₅₀ = 63.24 μg/mL) and total antioxidant capacity (TAC 37.84%). Antinociceptive activity was assessed through acetic acid-induced writhing, formalin, and tail flick tests. MfHE (25, 50, and 100 mg/kg, p.o.) significantly reduced writhes by 35.30%, 47.06%, and 66.47%, respectively, inhibited both phases of the formalin test, and increased latency in the tail flick test by 100% at 100 mg/kg. Anti-inflammatory effects were evaluated in carrageenan-induced paw edema and peritonitis models. MfHE reduced paw edema at all doses and lowered total leukocytes (34.57%, 49.39%, 67.91%), neutrophils (28.31%, 52.84%, 60.33%), and pro-inflammatory cytokines IL-1β (52.46%, 66.84%, 75.85%) and TNF-α (44.75%, 69.05%, 87.26%) in peritonitis test. These findings suggest that MfHE, rich in polyphenols, has promising antioxidant, antinociceptive, and anti-inflammatory properties.
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Registered trials
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