ArticleDiscover oncology2025
Amyloid precursor protein accumulation in glioblastoma is associated with altered synaptic dynamics and immune suppression.
Article in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Astrocytoma-Specific Prognostic Associations of Amyloid-Related Biological Processes.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- Metabolic-immune crosstalk in head and neck squamous cell carcinoma: CD44 and APP identified as causal therapeutic targets via integrated lactylation-Mendelian randomization analysis.Frontiers in immunology · 2026Article
- MALT1 in cerebrospinal fluid: a prognostic biomarker and potential therapeutic target in Alzheimer's disease.Frontiers in neurology · 2025Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Increased amyloid precursor protein (APP), including both mRNA and protein expression, has been linked to glioblastoma (GBM) yet the physiological effects are poorly understood. In this study, we investigated the relationship between APP protein abundance and mRNA expression in GBM. Gene set enrichment analysis revealed significant positive enrichment of neuron projection and synaptic junction gene sets from Gene Ontology. Additionally, several immune-related processes were negatively enriched, suggesting a broad immune suppression associated with increased presence of APP. These findings suggest a multi-faceted role of APP, linking its presence to modulation of synaptic activity as well as the immune microenvironment in GBM tumors.
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Registered trials
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