Evidence map›Paper›PMID 41003866›Full record

ReviewDiscover oncology2025

Therapeutic role of allicin in gastrointestinal cancers: mechanisms and safety aspects.

Abhishek Chauhan, Seeta Dewali, Vinay Mohan Pathak, Satpal Singh Bisht, Ritu Chauhan, Damandeep Kaur, Hardeep Singh Tuli, Shafiul Haque, Faraz Ahmad

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Garlic-Extract-Functionalized FeGels (Basel, Switzerland) · 2026
    Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abhishek ChauhanAmity Institute of Environmental Toxicology, Safety and Management, Amity University, Noida, 201303, India. akchauhan@amity.edu.
Seeta DewaliDepartment of Zoology, Kumaun University, Nainital, Uttarakhand, India.
Vinay Mohan PathakParwatiya Shiksha Sabha (PASS), Nainital, Haldwani, Uttarakhand, India.
Satpal Singh BishtDepartment of Zoology, Kumaun University, Nainital, Uttarakhand, India.
Ritu ChauhanDepartment of Biotechnology, Graphic Era (Deemed to Be University), Dehradun, Uttarakhand, 248002, India. rituachauhan25@gmail.com.
Damandeep KaurUniversity Center for Research & Development (UCRD), Chandigarh University, Gharuan, Mohali, Punjab, India.
Hardeep Singh TuliDepartment of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, 133207, India.
Shafiul HaqueDepartment of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan, 82911, Saudi Arabia.
Faraz AhmadDepartment of Biotechnology, School of Bio Sciences and Technology (SBST), Vellore Institute of Technology, Vellore, 632014, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Allicin, a bioactive compound found in garlic (Allium sativum), has shown significant potential in treating gastrointestinal cancers, including gastric, colorectal, liver, esophageal, and pancreatic cancers. This review focuses on the recent progress in the therapeutic application of this compound for the induction of apoptosis, inhibition of proliferation, and disruption of cancer cell signaling pathways, including the MAPK, PI3K/AKT, and NF-κB pathways. Taking these mechanisms into consideration, although challenging because of rapid metabolism and inherent instability, allicin could be a very potent candidate for cancer treatment. Allicin and its other derivatives, such as diallyl disulfide (DADS) and ajoene, have been found to have strong anticancer potential both in vitro and in vivo. In addition, the effectiveness of allicin in augmenting conventional chemotherapy and retarding tumor growth proves that allicin is one of the most efficient complementary therapies. Epidemiological studies have also demonstrated the role of garlic consumption in reducing the risk of developing cancer. This review examines the potential role of allicin in the treatment of gastrointestinal cancers and emphasizes the importance of this compound for future cancer biology research.

Indexed as

AllicinApoptosis inductionCancer cell signalling pathwaysComplementary therapyGastrointestinal cancer

Identifiers

PMID41003866
PMCPMC12474849

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.