Evidence map›Paper›PMID 41003798›Full record

ArticleTropical animal health and production2025

Relationship between bovine leukemia virus (BLV) infection and shedding provirus from milk in cows.

Mohammad Rahim Haji Hajikolaei, Shobeir Yazdani Paraei, M R Seyfi Abad Shapouri, Mohammad Nouri, Faramarz Beheshtifar, Şima Şahinduran

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Article in Tropical animal health and production, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Mohammad Rahim Haji HajikolaeiDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran. mhajih@scu.ac.ir.ORCID http://orcid.org/0000-0001-8964-8820
Shobeir Yazdani ParaeiDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
M R Seyfi Abad ShapouriDepartment of Pathobiology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Mohammad NouriDepartment of Clinical Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Faramarz BeheshtifarDepartment of Surgery, School of Medicine, Ahvaz Jundishpur University of Medical Sciences, Ahvaz, Iran.
Şima ŞahinduranBurdur Mehmet Akif Ersoy Üniversitesi, Faculty of Veterinary Medicine, Department of Internal Medicine, Burder, Turkey, Burdur, Turkey.

Funding

Shahid Chamran University of Ahvaz Shahid Chamran University of Ahvaz
6 · The paper itself

Abstract

Bovine leukemia virus (BLV), in addition to causing enzootic bovine leukosis (EBL), has been suspected as the cause of breast cancer in humans in the last decade. Since milk is one of the ways of excretion of the virus and transferring it to other cows or humans, this study was conducted to investigate the correlation between infection and shedding provirus BLV through milk. For this purpose, blood and milk samples were taken from 160 cows from 4 dairy farms in Tehran and Isfahan provinces of Iran. To detect antibodies to BLV, sera were tested by a commercial ELISA kit and Nested PCR were used for detection of BLV provirus in milks. Overall, 82.9% of the studied cows had antibodies to BLV in sera and 31.87% of them shed BLV provirus from milk. According to the result of ELISA and PCR, there was a significant difference between farms of Tehran and Isfahan. In addition, statistical analysis showed no-correlation between ELISA and milk PCR in all cows (Kappa = 0.038, P < 0.001). It is concluded that, although there is no significant correlation between infection with the virus and its shedding through milk, 31.9.2% of infected cattle shed the virus through milk, and there is a risk of infecting other cows and humans in this way. If it is proven that BLV is the definitive cause of breast cancer in humans, how to prevent its transmission through milk such as pasteurization should be investigated.

Indexed as

Enzootic Bovine LeukosisLeukemia Virus, BovineMilkProvirusesVirus SheddingAnimalsAntibodies, ViralCattleEnzyme-Linked Immunosorbent AssayFemaleIranPolymerase Chain ReactionAntibodies, ViralBovine leukemia virusCowELISAEnzootic bovine leucosisMilkPCR

Identifiers

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.