Evidence map›Paper›PMID 41003748›Full record

ArticleCurrent microbiology2025

Phylogenetic Studies on Taurine Dioxygenase (TauD).

Malini Sundar Rajan, Tamilselvan Jayavelu, Gautam Pennathur

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Article in Current microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Malini Sundar RajanCentre for Biotechnology, Anna University, Chennai, Tamil Nadu, 600025, India. maliniqrs@gmail.com.ORCID http://orcid.org/0000-0002-2498-1005
Tamilselvan JayaveluCentre for Biotechnology, Anna University, Chennai, Tamil Nadu, 600025, India.ORCID http://orcid.org/0000-0002-7143-352X
Gautam PennathurCentre for Biotechnology, Anna University, Chennai, Tamil Nadu, 600025, India.ORCID http://orcid.org/0000-0003-3140-3796

Funding

Department of Biotechnology, Ministry of Science and Technology, India DBT/2017/Anna Univ/966
6 · The paper itself

Abstract

Taurine dioxygenase (TauD) catalyses α-ketoglutarate-dependent oxidative decomposition of taurine and is grouped into an eponymous protein family (Pfam 02668-Taurine Catabolism Dioxygenase TauD, TfdA) with other enzymes that share this domain, but differ in substrates. In this study, we have detected Low Complexity Regions (LCRs) that set TauD apart from other members of its family. Using these regions, we designed patterns that reliably give true hits when queried against UniProt. We further demonstrate the use of these LCRs in detecting horizontal gene transfer (HGT) that led to TauD incorporation in at least one fungus genome. Additionally, we studied the genomic context of tauD across bacterial species and also performed promoter analysis to gain insights into its regulation. The tauABCD operon is restricted to certain genera of class Gammaproteobacteria with few exceptions, suggesting inheritance from a common ancestor. In other classes, TauD was found to have diverse genomic neighbours. Promoter analysis reveals several global and local regulators for tauABCD operon and other operons containing tauD.

Indexed as

BacteriaMixed Function OxygenasesPhylogenyBacterial ProteinsFungiGene Transfer, HorizontalOperonPromoter Regions, GeneticTaurineBacterial ProteinsMixed Function OxygenasesTaurinetaurine-alpha-ketoglutarate dioxygenase

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.