ArticleEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2025
Comprehensive surgical and reconstructive management with in-depth complication analysis of giant pediatric sarcomas: a two-center tertiary experience.
Article in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPediatric musculoskeletal sarcomas, though rare, pose significant therapeutic challenges due to tumor aggressiveness-particularly in tumors exceeding 10 cm-and the complexity of surgery in a growing population. Limb-salvage surgery aims to achieve oncologic control while preserving function and growth potential.
methodsWe retrospectively reviewed 45 pediatric patients (0-17 years) who underwent surgery for primary malignant musculoskeletal tumors > 10 cm at two tertiary centers (2016-2022). Demographic data, tumor characteristics, treatments, reconstruction techniques, complications, and oncological outcomes were descriptively analyzed.
resultsThe cohort primarily included Ewing sarcoma (56.8%) and osteosarcoma (31.8%). Limb salvage was achieved in 97.8% of patients, all with R0 margins. Reconstruction employed biological (46.7%) or endoprosthetic (40.0%) techniques; cryotherapy was used in 11.1%. Nearly half (48.8%) had an uncomplicated postoperative course. Short-term complications included infections (24%) and wound healing issues (15.6%), while mechanical failures were rare (6.6%). Over a median 60 month follow-up, local recurrence occurred in 4.4%, metastasis in 25%, and mortality in 18.8%. Functional outcomes were favorable, with low chronic pain (6.6%) and late bone deformity (2.2%).
conclusionsLimb-salvage surgery, guided by meticulous surgical planning and multidisciplinary reconstruction, offers excellent oncologic control and functional preservation in pediatric sarcoma patients with large tumors. Despite notable infection risk, vigilant perioperative care mitigates complications. Prospective studies are warranted to optimize long-term outcomes and evaluate emerging reconstructive technologies.
Indexed as
Identifiers
41003741What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.