Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
19 authors.
Douglas Souza OliveiraCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0001-8919-4996
César AlexandreLaboratory of Structural Biology, Instituto Butantan, São Paulo 05503-900, Brazil.
Miryam Paola Alvarez-FloresCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-7986-923X
Isadora Maria Villas-BoasCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0001-6034-9544
Hugo VigerelliCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-8197-2260
Isabel de Fátima Correia BatistaCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0001-7398-4184
Michelle Cristiane BufaloCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.
Nancy StarobinasCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0001-5716-3394
Flávio LichtensteinCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.
Rafael Marques-PortoLaboratory of Development and Innovation, Instituto Butantan, São Paulo 05503-900, Brazil.
Marcus BuriCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-8925-1206
Viviane Portas-LopesLaboratory of Development and Innovation, Instituto Butantan, São Paulo 05503-900, Brazil.
Pedro Luiz Mailho-FontanaLaboratory of Structural Biology, Instituto Butantan, São Paulo 05503-900, Brazil.
Marta Maria AntoniazziLaboratory of Structural Biology, Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-0575-7921
Denise Vilarinho TambourgiCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0003-1896-9074
Ana Marisa Chudzinski-TavassiCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.
Catarina TeixeiraCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0001-5887-7663
Carlos JaredLaboratory of Structural Biology, Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-9117-6276
Olga Martinez IbañezCentre of Excellence in New Target Discovery (CENTD), Instituto Butantan, São Paulo 05503-900, Brazil.ORCID 0000-0002-2672-4758
Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior 001Fundação Buntantan NAFundação de Amparo à Pesquisa do Estado de São Paulo 2020/13139-0
6 · The paper itself
Abstract
This study explores the direct effects of amphibian skin secretions on human cells involved in joint diseases, aiming to identify species with potential for inflammatory modulation. Secretions were obtained from sixteen species distributed across Brazilian biomes and one European species. Following biochemical characterization, human chondrocytes, synoviocytes, and macrophages were treated with secretions for 24 h. The cytotoxicity and modulation of the IL-6, IL-8, TNF-α, and IL-1β release were assessed. Synoviocytes showed the greatest resistance to cytotoxic effects, though sensitivity varied by species. Secretions from
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Biodiversity-Driven Screening of Amphibian Skin Secretions for Inflammatory Modulation in Joint Diseases. · full record | OpenQuestion