Evidence map›Paper›PMID 41003525›Full record

ArticleToxins2025

Sea Anemone-Derived Toxin Avd3i Inhibited Sodium Channel Nav1.4.

Jiaxin Gao, Guohao Liu, Yan Liu, Dezhao Zhang, Qinyi He, Qiong Liao, Canwei Du

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiaxin GaoSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.
Guohao LiuSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.
Yan LiuSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.
Dezhao ZhangThe National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, China.
Qinyi HeThe National & Local Joint Engineering Laboratory of Animal Peptide Drug Development, College of Life Sciences, Hunan Normal University, Changsha 410006, China.
Qiong LiaoHunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha 410006, China.
Canwei DuSchool of Life and Health Sciences, Hunan University of Science and Technology, Xiangtan 411201, China.ORCID 0000-0003-4722-9403

Funding

National Natural Science Foundation of China 82304448Natural Science Foundation of Hunan Province 2024JJ6225 2024JJ8216
6 · The paper itself

Abstract

Ion channels regulate ion transport across cell or organelle membranes, playing an important role in various biological processes. Sodium channel Nav1.4 is critical to initiating and propagating action potentials in skeletal muscles, and its dysfunction is associated with a variety of diseases, such as non-dystrophic myotonias. In this study, U-actitoxin-Avd3i (Avd3i), a Kunitz-type toxin derived from

Indexed as

Cnidarian VenomsNAV1.4 Voltage-Gated Sodium ChannelSea AnemonesVoltage-Gated Sodium Channel BlockersAnimalsHEK293 CellsHumansCnidarian VenomsNAV1.4 Voltage-Gated Sodium ChannelVoltage-Gated Sodium Channel BlockersAvd3iinhibitionNav1.4purification

Identifiers

PMID41003525
PMCPMC12474041

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.