Evidence map›Paper›PMID 41003497›Full record

ArticleToxins2025

Modification of Closed-State Inactivation in Voltage-Gated Sodium Channel Na

John W Johnson, Hillary G Rikli, Stephen R Johnson

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

John W JohnsonPharmacology Department, Southern Illinois University School of Medicine, Springfield, IL 62702, USA.
Hillary G RikliCarbon Dynamics Institute, LLC, Springfield, IL 62707, USA.
Stephen R JohnsonCarbon Dynamics Institute, LLC, Springfield, IL 62707, USA.ORCID 0000-0002-7025-4933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Venomous invertebrates have provided a large diversity of toxins that selectively and potently modulate ion channels that are indispensable tools for elucidating the structure and underlying mechanisms of these channels. Voltage-gated sodium channels (VGSC) are responsible for the initiation and propagation of action potentials in excitable cells and represent an important target for a variety of diseases. The Na

Indexed as

Arthropod VenomsNAV1.7 Voltage-Gated Sodium ChannelSpider VenomsAnimalsHumansXenopus laevisArthropod VenomsNAV1.7 Voltage-Gated Sodium ChannelSCN9A protein, humanSpider Venomsclosed-state inactivationhigh resolution mass spectrometrymass-to-charge ratioretention timetime-of-flighttotal ion chromatogramultra-performance liquid chromatographyvoltage-sensing domain

Identifiers

PMID41003497
PMCPMC12473925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.