Evidence map›Paper›PMID 41003496›Full record

ArticleToxins2025

Extract of

Galyna Shuvayeva, Mykola Tupychak, Olena Vovk, Dmytro Demash, Svitlana Chernyshuk, Yaroslav Bobak, Andriy Prokopiv, Nazariy Pokhodylo, Leoni A Kunz-Schughart, Mary T Fletcher and 1 more

Abstract read
In one paragraph

Article in Toxins, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Galyna ShuvayevaInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, 79005 Lviv, Ukraine.ORCID 0000-0001-7803-3900
Mykola TupychakDepartment of Organic Chemistry, Chemical Faculty, Ivan Franko National University of Lviv, Kyryla and Mefodiya Str., 6, 79005 Lviv, Ukraine.ORCID 0000-0002-9880-0983
Olena VovkInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, 79005 Lviv, Ukraine.ORCID 0000-0001-6703-457X
Dmytro DemashInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, 79005 Lviv, Ukraine.ORCID 0000-0002-1378-8402
Svitlana ChernyshukInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, 79005 Lviv, Ukraine.
Yaroslav BobakInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, 79005 Lviv, Ukraine.
Andriy ProkopivDepartment of Botany, Biological Faculty, Ivan Franko National University of Lviv, M. Hrushevskoho Str., 4, 79005 Lviv, Ukraine.ORCID 0000-0003-1690-4090
Nazariy PokhodyloDepartment of Organic Chemistry, Chemical Faculty, Ivan Franko National University of Lviv, Kyryla and Mefodiya Str., 6, 79005 Lviv, Ukraine.ORCID 0000-0001-8222-5008
Leoni A Kunz-SchughartOncoRay-National Center for Radiation Research in Oncology, Faculty of Medicine, University Hospital Carl Gustav Carus, TUD Dresden University of Technology and Helmholtz-Zentrum Dresden-Rossendorf, Fetscherstr 74, 01307 Dresden, Germany.ORCID 0000-0003-3912-6594
Mary T FletcherQueensland Alliance for Agriculture and Food Innovation (QAAFI), The University of Queensland, P.O. Box 156, Archerfield 4108, Australia.ORCID 0000-0003-0189-3376
Oleh StasykInstitute of Cell Biology, National Academy of Sciences of Ukraine, Drahomanov Str., 14/16, 79005 Lviv, Ukraine.

Funding

Bundesministerium für Forschung, Technologie und Raumfahrt No 01DK24023International Research and Training Center No 0124U003964National Research Foundation of Ukraine No 0124U003831Presidential Discretionary-Ukraine Support Grants" from Simons Foundation No 1030281
6 · The paper itself

Abstract

Metabolic anticancer therapy based on enzymatic arginine (Arg) deprivation (ADT) is currently being evaluated in clinical trials. The combination of ADT with low doses of the plant cytotoxic analogs of Arg, canavanine (Cav) or indospicine (Isp), have been proposed as being more efficient and selective against malignant cells. The leguminous plant

Indexed as

Antineoplastic Agents, PhytogenicColorectal NeoplasmsIndigoferaOvarian NeoplasmsPlant ExtractsArginaseArginineCell Line, TumorCell ProliferationCell SurvivalFemaleHumansAntineoplastic Agents, PhytogenicArginaseArgininePlant Extractsarginine deprivationIndigofera spicataindospicinemetabolic anticancer therapy

Identifiers

PMID41003496
PMCPMC12474036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.