ArticleTomography (Ann Arbor, Mich.)2025
Rethinking MRI Protocols for Pituitary Microadenomas: Prioritizing Non-Contrast Imaging for Safe Follow-Up.
Article in Tomography (Ann Arbor, Mich.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Pediatric endocrine disorders: a review of intracranial findings and appropriate imaging.Pediatric radiology · 2026Review
- A stacking model for AI-assisted diagnosis of suspected pituitary microadenomas on non-contrast T1COR MRI: a multicenter reader study on bridging the experience gap.Neuroradiology · 2026Article
- A multicenter-validated interpretable transformer model for pituitary microadenoma detection on non-contrast multiparametric MRI.BMC medical imaging · 2026Article
- Prolactinomas in women of reproductive age: a proposed reproductive-intent-based framework for diagnosis and management.Frontiers in endocrinology · 2026Review
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5 authors.
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Abstract
INTRODUCTION AND
objectivesDynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been used as a gold standard in diagnosing and following pituitary microadenomas. However, the use of gadolinium-based contrast agents (GBCAs) involves a potential risk of long-term retention in tissues and adverse reactions. This study aimed to evaluate the sensitivity of non-contrast MRI (T1W and T2W sequences) in follow-up imaging of pituitary microadenomas, attempting a comparison with DCE-MRI, assessing tumor stability over time. MATERIALS AND
methodsWe retrospectively reviewed 300 pituitary MRI scans between 2020 and 2024. Included were patients with confirmed microadenomas (≤10 mm). Non-contrast (T1W/T2W) and DCE-MRI sequences were analyzed by an experienced radiologist blinded to any clinical information. Detection rates and changes in tumor size were evaluated.
resultsDetection rates for 79 microadenomas were 55.7% for T1W, 70.9% for T2W, and 88.6% for DCE-MRI. There was no significant tumor growth during the follow-up (mean size 4.80 ± 2.3 mm vs. 4.81 ± 2.4 mm,
conclusionsWhile still more sensitive for the primary diagnosis, the non-contrast MRI was able to visualize the majority of detected microadenomas, and significant growth was ruled out, thus supporting the case to omit gadolinium from follow-up imaging in stable cases. This may translate to lower costs and decreased patient risk from contrast-related hazards.
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