Evidence map›Paper›PMID 41003388›Full record

ReviewJournal of functional biomaterials2025

Nature-Based Hydrogels Combined with Nanoparticles for Bone Regeneration.

Margarida Fernandes, Mónica Vieira, Daniela Peixoto, Natália M Alves

Abstract readReview
In one paragraph

Review in Journal of functional biomaterials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Margarida Fernandes3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradable and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), Barco, 4805-694 Guimarães, Portugal.
Mónica VieiraRISE-Health, Center for Translational Health and Medical Biotechnology Research (TBIO), ESS, Polytechnic of Porto, R. Dr. António Bernardino de Almeida, 400, 4200-072 Porto, Portugal.ORCID 0000-0002-8687-4811
Daniela Peixoto3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradable and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), Barco, 4805-694 Guimarães, Portugal.
Natália M Alves3B's Research Group, I3Bs-Research Institute on Biomaterials, Biodegradable and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, AvePark, Parque de Ciência e Tecnologia, Rua Ave 1, Edifício 1 (Sede), Barco, 4805-694 Guimarães, Portugal.ORCID 0000-0002-8741-4091

Funding

Fundação para a Ciência e Tecnologia "TERM RES Hub - Scientific Infrastructure for Tissue Engineering and Regenerative Medicine", reference PINFRA/22190/2016 (Norte-01-0145-FEDER-022190)Fundação para a Ciência e Tecnologia UID/50026:3 B ' s-Biomaterials, Biodegradables and Biomimetics Research Group, University of Minho (3B's Res. Group/UM)Maria Sklodowska-Curie grant SHIFT Project (funded by the European Union's Horizon 2020 Research and Innovation programme under the Maria Sklodowska-Curie grant agreement no. 101008041)
6 · The paper itself

Abstract

Bone is a calcified tissue composed of 60% inorganic compounds, 30% organic compounds, and 10% water. Bone exhibits an intrinsic regenerative capacity, enabling it to heal after fractures or adapt during growth. However, in cases of severe injury or extensive tissue loss, this regenerative capacity becomes insufficient, often necessitating bone graft surgeries using autografts or allografts. Conventional grafting approaches present several limitations, driving the development of alternative strategies in tissue engineering. The system of hydrogel-nanoparticles (NPs) represents a new class of biomaterials designed to combine the advantages of both materials while mitigating their drawbacks. This review focuses on a combination of nature-based hydrogels with different types of nanoparticles and discusses their potential applications in bone regeneration.

Indexed as

biomaterialsbonehydrogel systemsnanoparticles

Identifiers

PMID41003388
PMCPMC12470500

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.