Evidence map›Paper›PMID 41003306›Full record

ArticleMarine drugs2025

OSMAC-Driven Discovery of Six New Alkaloids from the Cold-Seep-Derived Fungus

Xinsheng Huang, Jiajin Wu, Luning Zhou, Zhengjie Wang, Qian Che, Liangzhen Chen, Wenxue Wang, Tianjiao Zhu, Dehai Li

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xinsheng HuangKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0009-0000-3540-9664
Jiajin WuKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Luning ZhouKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Zhengjie WangKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Qian CheKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0000-0003-0610-1593
Liangzhen ChenQingdao Institute of Innovation, East China University of Science and Technology, Qingdao 266003, China.
Wenxue WangKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Tianjiao ZhuKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0000-0003-4185-5593
Dehai LiKey Laboratory of Marine Drugs Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.ORCID 0000-0002-7191-2002

Funding

the Funda-mental Research Funds for the Central Universities 202172002, 202172009, and 202262015the Key R&D Pro-gram of Hainan Province ZDYF2023SHFZ144the Major Basic Research Programs of Natural Science Foundation of Shandong Province ZR2019ZD18the National Key R&D Program of China 2024YFC2816004the Qingdao Marine Science and Technology Center 2022QNLM030003-1the Research on the Development Strategy of Qingdao's Synthetic Biology Future Industry 25-1-4-zlyj-16-zhcthe Taishan Scholar Distinguished Expert Program in Shandong Province tstp20240504
6 · The paper itself

Abstract

Six new alkaloid compounds, including two rare aromatic nitrile compounds talaronitriles A-B (

Indexed as

AlkaloidsTalaromycesDrug DiscoveryFree Radical ScavengersMolecular StructureAlkaloidsFree Radical Scavengersalkaloidsazaphilone analoguecyanated derivativesOSMACTalaromyces amestolkiae

Identifiers

PMID41003306
PMCPMC12472177

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.