ReviewMedical sciences (Basel, Switzerland)2025
Unmasking Left Ventricular Diastolic Dysfunction: Pathophysiology, Diagnosis, and Treatment Strategies.
Review in Medical sciences (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Noninvasive Estimation of Left Ventricular End-Diastolic Pressure Through a Mechanical Seal for a Rotary Blood Pump.Artificial organs · 2026Article
- Impact of the 2025 ASE Updated Recommendations on the Diagnosis of Left Ventricular Diastolic Dysfunction in Asymptomatic Elderly Inpatients With Preserved Ejection Fraction: A Multi-Center Retrospective Study.Echocardiography (Mount Kisco, N.Y.) · 2026Article
- Multimodality echocardiography in structural heart disease: the evolving role of the interventional imager.European heart journal. Imaging methods and practice · 2026Review
- [Heart failure with preserved ejection fraction in old age : Diagnostic strategies in clinical practice].Zeitschrift fur Gerontologie und Geriatrie · 2026Article
- Mechanistic Role of Sestrin2 in Exercise-Mediated Cardioprotection Against Obesity-Related Cardiomyopathy.International journal of molecular sciences · 2026Article
- Intersecting Molecular Pathways in Cardiovascular Disease and Diabetes Mellitus: Emerging Roles of Inflammation and Therapeutics.Diabetes/metabolism research and reviews · 2026Review
- The Prognostic Value of Exercise Stress Echocardiography in Asymptomatic Moderate and Severe Aortic Stenosis: A Systematic Review of Stress-Derived Hemodynamic and Functional Markers.Journal of clinical medicine · 2026Review
- Hypovolemic Shock in the Setting of Third Spacing with Concentric Left Ventricular Hypertrophy: A Physiology-Guided Management of Fluid Resuscitation-Case Report and Literature Review.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Article
- The nonlinear association between Body Roundness Index and left ventricular diastolic dysfunction in type 2 diabetes.Frontiers in endocrinology · 2026Article
- Left ventricular diastolic dysfunction: the missing window for early intervention in diabetic cardiomyopathy.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Left ventricular diastolic dysfunction (LVDD) is characterized by impaired ventricular relaxation and increased chamber stiffness during diastole, resulting in increased left ventricular filling pressures. It represents a highly prevalent yet frequently underdiagnosed cardiac condition with significant clinical implications, serving as a major contributor to heart failure with preserved ejection fraction (HFpEF), particularly among elderly individuals and those with hypertension, diabetes mellitus, obesity, or coronary artery disease. Multiple studies have identified the progression of LVDD as a marker of adverse prognosis, associated with increased morbidity and mortality, highlighting the importance of early recognition and targeted therapeutic strategies to improve diastolic function and clinical outcomes. This review summarizes the pathophysiology, current diagnostic strategies, and treatment options for LVDD, emphasizing its importance in clinical practice.
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