Evidence map›Paper›PMID 41003118›Full record

ReviewJournal of personalized medicine2025

The Role of Orbital Atherectomy for Complex Coronary Calcium Modification: Has It Been Eclipsed?

Natasha Khullar, Trisha Singh, Peter O'Kane, Jonathan Hinton

Abstract readReview
In one paragraph

Review in Journal of personalized medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Natasha KhullarDorset Heart Centre, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK.ORCID 0000-0003-0949-7095
Trisha SinghDorset Heart Centre, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK.
Peter O'KaneDorset Heart Centre, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK.
Jonathan HintonDorset Heart Centre, Royal Bournemouth Hospital, Castle Lane East, Bournemouth BH7 7DW, UK.ORCID 0000-0003-1670-5550

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe coronary artery calcification (CAC) is a frequent finding in patients undergoing percutaneous coronary intervention (PCI) and represents a significant procedural challenge. CAC is commonly associated with ageing and comorbidities such as diabetes, hypertension, and chronic kidney disease, and contributes to vessel rigidity, impaired device delivery, and suboptimal stent expansion. These factors increase the risk of angiographic complications, as well as major adverse cardiac events compared with non-calcified lesions, negatively impacting both immediate and long-term clinical outcomes. In cases of severe calcification, traditional balloon angioplasty is often inadequate, necessitating the use of dedicated calcium modification techniques. Devices such as rotational atherectomy (RA), orbital atherectomy (OA), excimer laser coronary atherectomy (ELCA), and intravascular lithotripsy (IVL) have been developed to address these challenges. Among these, orbital atherectomy offers a potential unique dual mechanism of action and has shown promise in enhancing lesion preparation and facilitating optimal stent deployment. This review provides an overview of the role of orbital atherectomy in the management of calcified coronary lesions, evaluates current evidence on its safety and efficacy, and discusses how it may be positioned in the future, underscoring the need for a personalised, lesion-specific approach to optimise PCI outcomes.

Indexed as

coronary calcificationorbital atherectomypercutaneous coronary intervention

Identifiers

PMID41003118
PMCPMC12471242

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.