Evidence map›Paper›PMID 41003037›Full record

ArticleNanomaterials (Basel, Switzerland)2025

Humics-Functionalized Iron(III) Oxyhydroxides as Promising Nanoferrotherapeutics: Synthesis, Characterization, and Efficacy in Iron Delivery.

Anastasiya M Zhirkova, Maria V Zykova, Evgeny E Buyko, Karina A Ushakova, Vladimir V Ivanov, Denis A Pankratov, Elena V Udut, Lyudmila A Azarkina, Sergey R Bashirov, Evgenii V Plotnikov and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anastasiya M ZhirkovaDepartment of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow 119991, Russia.
Maria V ZykovaPharmaceutical Faculty, Siberian State Medical University, Tomsk 634050, Russia.ORCID 0000-0002-1973-8983
Evgeny E BuykoPharmaceutical Faculty, Siberian State Medical University, Tomsk 634050, Russia.ORCID 0000-0002-6714-1938
Karina A UshakovaDepartment of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow 119991, Russia.
Vladimir V IvanovPharmaceutical Faculty, Siberian State Medical University, Tomsk 634050, Russia.
Denis A PankratovDepartment of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow 119991, Russia.ORCID 0000-0001-6557-2753
Elena V UdutPharmaceutical Faculty, Siberian State Medical University, Tomsk 634050, Russia.ORCID 0000-0002-6104-4782
Lyudmila A AzarkinaPharmaceutical Faculty, Siberian State Medical University, Tomsk 634050, Russia.
Sergey R BashirovPharmaceutical Faculty, Siberian State Medical University, Tomsk 634050, Russia.ORCID 0000-0001-6381-1327
Evgenii V PlotnikovResearch School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia.ORCID 0000-0002-4374-6422
Alexey N PestryakovResearch School of Chemistry and Applied Biomedical Sciences, Tomsk Polytechnic University, Tomsk 634050, Russia.ORCID 0000-0002-9034-4733
Mikhail V BelousovPharmaceutical Faculty, Siberian State Medical University, Tomsk 634050, Russia.ORCID 0000-0002-2153-7945
Irina V PerminovaDepartment of Chemistry, Lomonosov Moscow State University, Leninskiye Gory 1-3, Moscow 119991, Russia.ORCID 0000-0001-9084-7851

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Iron deficiency anemia (IDA) remains a global health challenge. This study pioneers the use of humic substances (HS) as natural, biocompatible macroligands to develop safer and more effective nanoferrotherapeutics. We synthesized a series of nanoscale Fe(III) oxyhydroxide complexes stabilized by different HS, employing various solvents (ethanol, isopropanol, and acetone) and precipitation methods to isolate fractions with optimized properties. The nanocomposites were comprehensively characterized using inductively coupled plasma atomic emission spectrometry, total organic carbon analysis, X-ray diffraction, transmission electron microscopy, and Mössbauer spectroscopy. Cytotoxicity and iron bioavailability of all HS-Fe(III) formulations were assessed in Caco-2 intestinal epithelial cells. The type of HS and precipitation conditions significantly influenced the nanocomposites' properties, yielding spherical nanoparticles (1-2 nm) of ferrihydrite or goethite. Physicochemical analysis confirmed that solvent-driven fractionation effectively tailored the nanocomposites' size, crystallinity, and elemental composition. All HS-Fe(III) formulations demonstrated exceptional cytocompatibility, starkly contrasting the significant cytotoxicity of the reference drug Ferrum Lek

Indexed as

alcohol precipitationbioavailabilitycell culturecytotoxicityhumic substancesiron nanoparticlessynthesis

Identifiers

PMID41003037
PMCPMC12472974

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.