ArticleNeurology international2025
Plasma Neurofilament Light Chain Is Associated with Cognitive Functions but Not Patient-Reported Outcomes in Multiple Sclerosis.
Valerio Nicolella, Federica Novarella, Fabrizia Falco, Carmela Polito, Rosa Sirica, Evelina La Civita, Vincenzo Criscuolo, Giuseppe Corsini, Antonio Luca Spiezia, Alessia Castiello and 7 more
Abstract read
In one paragraphArticle in Neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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5 · Who and what moneyAuthors and funding
17 authors.
Valerio NicolellaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0009-0009-0756-9877 Federica NovarellaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.
Fabrizia FalcoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0002-4585-1867 Carmela PolitoDepartment of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy.
Rosa SiricaDepartment of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy.
Evelina La CivitaDepartment of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy.
Vincenzo CriscuoloDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
Giuseppe CorsiniDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0009-0001-2377-6181 Antonio Luca SpieziaDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0003-3287-3247 Alessia CastielloDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.
Antonio CarotenutoDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0002-1574-9693 Maria PetraccaDepartment of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Roberta LanzilloDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0001-6388-8180 Giuseppe CastaldoDepartment of Molecular Medicine and Medical Biotechnology, Federico II University of Naples, 80131 Naples, Italy.
Vincenzo Brescia MorraDepartment of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University of Naples, 80131 Naples, Italy.
Daniela TerraccianoDepartment of Translational Medical Sciences, Federico II University of Naples, 80131 Naples, Italy.ORCID 0000-0003-4296-429X Marcello MocciaMultiple Sclerosis Unit, Policlinico Federico II University Hospital, 80131 Naples, Italy.ORCID 0000-0003-2613-3090 Funding
Campania Region NeuroDiaTE Project CUP E65E24002260002MUR PNRR Extended Partnership DHEAL-COM no. PNC-E3- 2022-23683267MUR PNRR Extended Partnership MNESYS no. PE00000006
6 · The paper itselfAbstract
objectiveWe aimed to explore associations between plasma neurofilament light chain (pNfL) and cognition through patient-reported outcomes (PROs) in multiple sclerosis (MS).
methodsIn this cross-sectional study, we included 211 people with MS (PwMS) and collected data from pNfL (fully automated chemiluminescent enzyme immunoassay), EDSS, education, cognition (the Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-II (CVLT II), and Brief Visuospatial Memory Test-Revised (BVMT-R)), the Modified Fatigue Impact Scale (MFIS), Beck Depression Inventory (BDI-II), Beck Anxiety Inventory (BAI), and Pittsburgh Sleep Quality Index (PSQI).
resultsOn multivariate linear regression models, higher educational attainment was significantly associated with lower pNfL (high school: Coeff = -0.22, 95% CI = -0.41 to -0.04,
conclusionsNeuro-axonal damage in people with MS manifests clinically as increased disability and reduced attention and processing speed. However, these effects may be mitigated by greater brain resilience, as suggested by the protective role of higher educational attainment. The PROs assessed in this study showed no significant associations with pNfL levels, possibly due to measurement errors and heterogeneity, with limited sensitivity to neuro-axonal damage.
Indexed as
cognitivemultiple sclerosisneurofilamentpatient-reported outcomes
Identifiers
PMID41002932
PMCPMC12472482
What OpenQuestion holds
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LicenceCC BY
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