ArticleBiomimetics (Basel, Switzerland)2025
Biomimetic Dual-Sensing Bone Scaffolds: Characterization and In Vitro Evaluation Under Dynamic Culturing Conditions.
Article in Biomimetics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Bone Tissue Engineering: Scaffold Design Principles, Biomaterial Advances, and Strategies for Functional Regeneration and Clinical Translation.Bioengineering (Basel, Switzerland) · 2026Review
- Scaffold Design: A Review of Material and Immune Modulation in Bone Tissue Engineering.Cell and tissue banking · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The regeneration of large segmental bone defects remains a significant challenge. While electrical stimulation has demonstrated the potential to accelerate bone healing, clinical translation has been hindered by the lack of safe, localized delivery methods. In this study, we present a novel strategy combining piezoelectric and electrically conductive polymers with allograft demineralized bones to create stimuli-responsive, biologically relevant scaffolds via pneumatic 3D printing. These scaffolds exhibit enhanced piezoelectric potential and tunable electrical properties, enabling both electrical and mechanical stimulation of cells (without external stimulators). Under dynamic culturing conditions (i.e., ultrasound stimulation), human bone marrow-derived mesenchymal stromal cells cultured on these scaffolds displayed significantly elevated osteogenic protein expression (i.e., alkaline phosphatase and osteocalcin) and mineralization (confirmed via xylenol orange mineral staining) after two weeks. This work introduces a bioinspired, printable ink in conjunction with a simple fabrication approach for creating dual-responsive scaffolds with high potential for functional bone tissue regeneration.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.