NADES-Mediated Deposition of Potential Biomimetic Drug-Loaded Polypyrrole on Biomedical Ti20Zr5Ta2Ag.

Radu Nartita, Florentina Golgovici, Ioana Demetrescu

Abstract read

In one paragraph

Article in Biomimetics (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

3 authors.

Radu NartitaDepartment of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Splaiul Independentei Street, No. 313, 060042 Bucharest, Romania.

Florentina GolgoviciDepartment of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Splaiul Independentei Street, No. 313, 060042 Bucharest, Romania.ORCID 0000-0002-4943-1448

Ioana DemetrescuDepartment of General Chemistry, Faculty of Chemical Engineering and Biotechnologies, National University of Science and Technology Politehnica Bucharest, Splaiul Independentei Street, No. 313, 060042 Bucharest, Romania.ORCID 0000-0001-6624-0195

Funding

the National Program for Research of the National Association of Technical Universities GNAC ARUT 2023

6 · The paper itself

Abstract

A natural deep eutectic solvent (NADES)-based electropolymerization strategy was developed to deposit polypyrrole (PPy) and Naproxen-doped PPy films onto a biomedical Ti-20Zr-5Ta-2Ag high-entropy alloy. Using cyclic voltammetry, chronoamperometry, and chronopotentiometry, coatings were grown potentiostatically (1.2-1.6 V) or galvanostatically (0.5-1 mA) to fixed charge values (1.6-2.2 C). Surface morphology and composition were assessed by optical microscopy, SEM and FTIR, while wettability was quantified via static contact-angle measurements in simulated body fluid (SBF). Electrochemical performance in SBF was evaluated through open-circuit potential monitoring, potentiodynamic polarization, and electrochemical impedance spectroscopy. Drug-release kinetics were determined by UV-Vis spectrophotometry and analyzed using mathematical modelling. Compared to uncoated alloy, PPy and PPy-Naproxen coatings increased hydrophilicity (contact angles reduced from ~31° to <10°), and reduced corrosion current densities from 754 µA/cm

Indexed as

corrosion protectiondrug releasehigh-entropy alloyNaproxennatural deep eutectic solventpolypyrrole

Identifiers

PMID41002801

DOI10.3390/biomimetics10090568

PMCPMC12467814

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