Evidence map›Paper›PMID 41002590›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

Expression of Keratin-1 Predicts Recurrence and Treatment Response in Advanced Laryngeal Cancer: A Potential Therapeutic Target.

Eun Kyung Jung, S M Abdus Salam, Hye-Bin Jang, Joo Yeon Koo, Eshrat Jahan, Sun-Ae Kim, Ji Young Lee, Kyung-Hwa Lee, Tae Mi Yoon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eun Kyung JungDepartment of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.
S M Abdus SalamDepartment of Pathology, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.ORCID 0000-0003-4347-7370
Hye-Bin JangDepartment of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.
Joo Yeon KooDepartment of Pathology, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.ORCID 0000-0003-0551-5954
Eshrat JahanDepartment of Pathology, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.ORCID 0009-0008-5744-9315
Sun-Ae KimDepartment of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.
Ji Young LeeDepartment of Pathology, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.ORCID 0009-0005-1192-6698
Kyung-Hwa LeeDepartment of Pathology, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.ORCID 0000-0002-3935-0361
Tae Mi YoonDepartment of Otolaryngology-Head and Neck Surgery, Chonnam National University Medical School and Hwasun Hospital, Gwangju 58128, Republic of Korea.

Funding

National Research Foundation of Korea 2020M3A9G3080330National Research Foundation of Korea 2020R1F1A1076054
6 · The paper itself

Abstract

The survival rate of patients with advanced laryngeal cancer has not substantially improved over time. RNA sequencing analysis identified Keratin-1 (KRT1) as a gene potentially associated with cancer recurrence. This study investigated the association between KRT1 expression and recurrence in advanced laryngeal cancer. RNA sequencing was performed to identify candidate genes associated with recurrence. The effects of KRT1 expression on clinical outcomes were evaluated in patients with laryngeal cancer. Multiple experimental techniques were utilized. RNA sequencing of patient samples demonstrated higher KRT1 gene expression in the recurrence group than in non-recurrent cases. Patients with KRT1-positive immunostaining exhibited trends of worse overall survival (OS) and recurrence-free survival (RFS). In vitro studies showed that KRT1 knockdown suppressed tumor cell invasion, cell migration, and expression of epithelial-mesenchymal transition (EMT)-related genes in human head and neck squamous cell carcinoma (HNSCC) cell lines. KRT1 knockdown enhanced tumor cell apoptosis and exhibited synergistic effects with conventional radiation and chemotherapy treatments. KRT1 may serve as a biomarker for predicting advanced laryngeal cancer recurrence and assist with selecting patients to receive concurrent chemoradiotherapy (CCRT). Further molecular investigations are warranted to determine its effects, but KRT1 has potential as a therapeutic target.

Indexed as

Biomarkers, TumorKeratin-1Laryngeal NeoplasmsNeoplasm Recurrence, LocalSquamous Cell Carcinoma of Head and NeckAdultAgedAged, 80 and overCell Line, TumorChemoradiotherapyDisease-Free SurvivalEpithelial-Mesenchymal TransitionFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansBiomarkers, TumorKeratin-1KRT1 protein, humankeratin-1laryngeal cancermolecular targeted therapyradioresistancerecurrence

Identifiers

PMID41002590
PMCPMC12468875

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.