Evidence map›Paper›PMID 41002552›Full record

ArticleCurrent oncology (Toronto, Ont.)2025

De-Escalation of Treatment in Women Aged ≥80 Years with Breast Cancer: A Retrospective Analysis from Two Breast Centers.

Gianmarco Piccolino, Giulia Cardelli, Francesca Arienzo, Emanuele Zarba Meli, Elena Del Giudice, Leopoldo Costarelli, Rosalinda Rossi, Claudia Scaringi, Tiziana Mastropietro, Laura Broglia and 8 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Gianmarco PiccolinoBreast Center, Department of Surgery, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Giulia CardelliDepartment of Surgical Science, University of Rome, "Tor Vergata" Hospital, 00133 Rome, Italy.
Francesca ArienzoPathology Unit, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Emanuele Zarba MeliBreast Center, Department of Surgery, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Elena Del GiudiceGeriatric Unit, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Leopoldo CostarelliPathology Unit, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.ORCID 0000-0002-9545-8123
Rosalinda RossiDepartment of Oncology, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Claudia ScaringiRadiotherapy Unit, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Tiziana MastropietroBreast Center, Department of Surgery, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Laura BrogliaBreast Radiology, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Valeria VitaleDepartment of Surgical Science, University of Rome "La Sapienza", Sant' Andrea Hospital, 00189 Rome, Italy.
Federica BergamoDepartment of Surgical Science, University of Rome "La Sapienza", Sant' Andrea Hospital, 00189 Rome, Italy.
Elena MannaBreast Center, Department of Surgery, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Massimo La PintaBreast Center, Department of Surgery, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Lorenzo PalleschiGeriatric Unit, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.
Andrea LoretiBreast Center, Department of Surgery, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.ORCID 0009-0000-7378-8431
Augusto LombardiDepartment of Surgical Science, University of Rome "La Sapienza", Sant' Andrea Hospital, 00189 Rome, Italy.ORCID 0000-0002-4520-0183
Lucio FortunatoBreast Center, Department of Surgery, San Giovanni-Addolorata Hospital, 00184 Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer is frequently diagnosed in older women. However, the impact of surgery on survival is not well studied and prognosis for women ≥ 80 years of age is progressively depending on comorbidities.

methodsMedical records of consecutive women aged ≥ 80 years diagnosed with primary breast cancer treated with upfront surgery at two Breast Centers from 2011 to 2021 were retrospectively analyzed.

resultsA total of 553 consecutive women with a median age of 83 years and a median tumor diameter of 21 mm were analyzed (574 lesions). Clinical Stages II or III were found in 263/574 (46%) and 101/574 cases (18%), respectively. Axillary staging was completely omitted for 94/542 invasive lesions (17%), and this increased over time from 2% to 33% (

conclusionsBreast surgery, when possible, has a primary role even for women > 80 years of age, and it is associated with a reasonable BCSS. De-escalation of adjuvant therapies should be considered in this setting because survival is largely determined by age and co-morbidities.

Indexed as

Breast NeoplasmsAged, 80 and overChemotherapy, AdjuvantFemaleHumansRetrospective Studiesbreast cancerolder adultssurgery

Identifiers

PMID41002552
PMCPMC12468118

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