ArticleGels (Basel, Switzerland)2025
Development of an Innovative Nanosystem Based on Functionalized Albumin and Oxidized Gellan for the Synergistic Delivery of Curcumin and Temozolomide in the Treatment of Brain Cancer.
Camelia Elena Iurciuc Tincu, Gabriela Vochița, Daniela Gherghel, Cosmin-Teodor Mihai, Silvia Vasiliu, Ștefania Racoviță, Anca Niculina Cadinoiu, Corina Lenuța Logigan, Mihaela Hamcerencu, Florin Mitu and 2 more
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In one paragraphArticle in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
12 authors.
Camelia Elena Iurciuc TincuDepartment of Natural and Synthetic Polymers, "Cristofor Simionescu" Faculty of Chemical Engineering and Protection of the Environment, "Gheorghe Asachi" Technical University, 73, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania.
Gabriela VochițaInstitute of Biological Research Iasi, Branch of National Institute of Research and Development for Biological Science, 47, Lascar Catargi Street, 700107 Iasi, Romania.
Daniela GherghelInstitute of Biological Research Iasi, Branch of National Institute of Research and Development for Biological Science, 47, Lascar Catargi Street, 700107 Iasi, Romania.ORCID 0000-0002-9601-7928 Cosmin-Teodor MihaiDepartment of Medical Genetics, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16, University Street, 700115 Iasi, Romania.ORCID 0000-0002-0945-5437 Silvia Vasiliu"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley, No. 41A, 700487 Iasi, Romania.
Ștefania Racoviță"Petru Poni" Institute of Macromolecular Chemistry, Grigore Ghica Voda Alley, No. 41A, 700487 Iasi, Romania.ORCID 0000-0001-9653-707X Anca Niculina CadinoiuFaculty of Dental Medicine, "Apollonia" University of Iasi, 11, Pacurari Street, 700511 Iasi, Romania.ORCID 0000-0002-3708-3992 Corina Lenuța LogiganDepartment of Natural and Synthetic Polymers, "Cristofor Simionescu" Faculty of Chemical Engineering and Protection of the Environment, "Gheorghe Asachi" Technical University, 73, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania.ORCID 0000-0002-4494-3583 Mihaela HamcerencuLaboratoire de Photochimie et Ingénierie Macromoléculaires-Ecole Nationale Supérieure de Chimie de Mulhouse, Université de Haute Alsace, 3 Rue Alfred Werner, 68093 Mulhouse Cedex, France.ORCID 0000-0002-5157-2952 Florin MituDepartment of Medical Specialties (I), Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, University Street, 700115 Iasi, Romania.
Marcel PopaDepartment of Natural and Synthetic Polymers, "Cristofor Simionescu" Faculty of Chemical Engineering and Protection of the Environment, "Gheorghe Asachi" Technical University, 73, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania.ORCID 0000-0003-4929-0830 Lăcrămioara OchiuzDepartment of Pharmaceutical Technology, Faculty of Pharmacy, "Grigore T. Popa" University of Medicine and Pharmacy, 16, University Street, 700115 Iasi, Romania.ORCID 0000-0001-6447-0958 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Treating brain cancer remains challenging due to the blood-brain barrier (BBB) and the systemic toxicity of chemotherapy. This study focuses on developing human serum albumin (HSA) nanoparticles modified with low-molecular-weight protamine (LMWP) to improve crossing the BBB and enable targeted delivery of curcumin and temozolomide (TMZ). Nanoparticle stability was enhanced by crosslinking with aldehyde groups from oxidized gellan (OG). The successful attachment of LMWP to HSA at the thiol group of Cys34 was confirmed through FT-IR and
Indexed as
functionalization of human serum albuminHSA-based nanoparticlesovercoming blood–brain barrieroxidized gellan crosslinkingsynergic effect of co-encapsulated curcumin and temozolomidetarget delivery
Identifiers
PMID41002483
PMCPMC12469971
What OpenQuestion holds
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LicenceCC BY
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