Evidence map›Paper›PMID 41002457›Full record

ArticleGels (Basel, Switzerland)2025

An Advanced Adhesive Electrolyte Hydrogel Intended for Iontophoresis Enhances the Effective Delivery of Glycolic Acid Via Microbeads.

Mariia Kazharskaia, Yu Yu, Chenguang Liu

Abstract read
In one paragraph

Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mariia KazharskaiaCollege of Marine Life Sciences, Ocean University of China, No.5 Yushan Road, Qingdao 266003, China.ORCID 0009-0001-8613-8566
Yu YuCollege of Marine Life Sciences, Ocean University of China, No.5 Yushan Road, Qingdao 266003, China.
Chenguang LiuCollege of Marine Life Sciences, Ocean University of China, No.5 Yushan Road, Qingdao 266003, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents an innovative iontophoretic delivery system for glycolic acid (GA) based on polysaccharide microbeads embedded within an electrolyte hydrogel. The mi-crobeads, fabricated using a peristaltic pump, exhibited a uniform morphology with an average diameter of 1078 ± 140.38 μm and were successfully integrated into a hydrogel matrix (thickness: 4542.55 ± 337.24 μm). Comprehensive physicochemical characterization (FT-IR, XRD, SEM) confirmed effective component integration. The hydrogel demonstrated optimal mechanical properties with a tensile strength of 0.02 ± 0.003 MPa and reliable adhesion to various substrates, while maintaining excellent self-healing capabili-ties-post-repair conductivity remained sufficient to power an LED indicator. The material demonstrated favorable conductivity under various storage conditions while maintaining non-cytotoxic properties. Notably, microbead incorporation preserved electrochemical performance, as demonstrated by stable behavior in cyclic voltammetry using an Ag/AgCl reference system. Iontophoretic testing revealed significantly enhanced glycolic acid delivery at -1.0 V com-pared to passive diffusion. The system, combining PVA, PAA, alginate, [Bmim]BF

Indexed as

electrolyte hydrogelglycolic acidiontophoresismicrobead

Identifiers

PMID41002457
PMCPMC12470250

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.