ArticleCells2025
Use of Amplified Lewy Body Dementia Fibrils and Autoradiography to Characterize Binding of Radioligand Tg-1-90B to Alpha-Synuclein Fibrils in Postmortem Brain Tissue.
Jennifer Y O'Shea, Dhruva D Dhavale, Helen Hwang, Zachary Smith, Thomas J A Graham, Robert H Mach, Paul T Kotzbauer
Abstract read
In one paragraphArticle in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Jennifer Y O'SheaDepartment of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-5492-1847 Dhruva D DhavaleDepartment of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.ORCID 0000-0002-0096-1085 Helen HwangDepartment of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
Zachary SmithDepartment of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
Thomas J A GrahamDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Robert H MachDepartment of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7645-2869 Paul T KotzbauerDepartment of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA.
Funding
Medicinal Chemistry CoreU19NS110456 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI ROBERT H MACH · 2019 to 2026
$44.1MStructural Biology of Alpha-Synuclein in Lewy Body DementiaRF1NS110436 · NINDS · WASHINGTON UNIVERSITY · PI KOTZBAUER, PAUL T, RIENSTRA, CHAD M · 2023 to 2023
$4.2MSTRUCTURAL BIOLOGY OF ALPHA-SYNUCLEIN IN LEWY BODY DEMENTIAU01NS110436 · NINDS · WASHINGTON UNIVERSITY · PI KOTZBAUER, PAUL T · 2018 to 2022
$4.1MMichael J. Fox Foundation Consortium to Develop an Alpha-synuclein Imaging AgentNIH HHS 1U19NS110456-05NIH HHS 2RF1NS110436-06NINDS NIH HHS RF1 NS110436NINDS NIH HHS U01 NS110436NINDS NIH HHS U19 NS110456
6 · The paper itselfAbstract
Parkinson's disease (PD) and Lewy Body Dementia (LBD) are defined by accumulation of alpha-synuclein (Asyn) fibrils within Lewy bodies (LBs) and Lewy neurites (LNs). The development of a Positron Emission Tomography (PET) tracer for quantifying Asyn fibrils would improve diagnostic accuracy and provide a biomarker for disease progression. We previously described radioligand [
Indexed as
alpha-SynucleinAutoradiographyBrainLewy Body DiseaseAgedAged, 80 and overAutopsyFemaleHumansLewy BodiesLigandsMaleMolecular Docking SimulationPositron-Emission TomographyProtein BindingRadioligand Assayalpha-SynucleinLigandsalpha-synuclein fibrilsamplified LBD fibrilsautoradiographyfibril structureLewy body dementiaParkinson’s diseaseradioligand bindingTg-1-90B
Identifiers
PMID41002442
PMCPMC12468313
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