Evidence map›Paper›PMID 41002438›Full record

ArticleCells2025

Pericyte Expression of VEGF-A Minimally Impacts Ocular Vascular Development and Neovascularization.

Yong-Seok Song, Shoujian Wang, Samay Inampudi, Hope Risa, Christine M Sorenson, Nader Sheibani

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Mechanisms of Pericyte-Mediated Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yong-Seok SongDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Shoujian WangDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Samay InampudiDepartment of Pediatrics, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Hope RisaDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Christine M SorensonMcPherson Eye Research Institute, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.
Nader SheibaniDepartment of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, WI 53705, USA.ORCID 0000-0003-2723-9217

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
UW Vision Research Core - Administrative CoreP30EY016665 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI AKIHIRO IKEDA · 2005 to 2026
$12.6M
VEGF Antagonism and Resistance to Neovascular AMDR01EY030076 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2020 to 2023
$1.5M
Bcl-2, Subretinal Scar Formation and Neovascular AMDR21EY034646 · NEI · UNIVERSITY OF WISCONSIN-MADISON · PI SORENSON, CHRISTINE M · 2023 to 2023
$428k
NCI NIH HHS P30 CA014520NEI NIH HHS P30 EY016665NEI NIH HHS R01 EY030076NEI NIH HHS R21 EY034646NIH HHS P30 EY016665, P30 CA014520, EY034646 and EY030076Research to Prevent Blindness Steine Innovation AwardResearch to Prevent Blindness Unrestricted Award to the Department of Ophthalmology and Visual SciencesRetina Research Foundation Endoument AwardRRF/Daniel M. Albert Chair Endoument Award
6 · The paper itself

Abstract

Pericytes produce vascular endothelial growth factor-A (VEGF-A; hereafter referred to as VEGF). VEGF inhibits pericyte proliferation and migration through enhanced VEGFR2 and PDGFRβ heterodimerization. Heterodimerization of these receptors on perivascular supporting cells, mediated by VEGF in culture, mitigates signaling through these receptors and promotes a quiescent phenotype. However, the detailed cellular mechanisms and the significance of these interactions in vivo require further investigation. The cell-autonomous activities of pericyte VEGF expression during vascular development and neovascularization remain unknown. Here we utilized mice conditionally lacking

Indexed as

Neovascularization, PathologicNeovascularization, PhysiologicPericytesRetinal NeovascularizationRetinal VesselsVascular Endothelial Growth Factor AAnimalsEndothelial CellsMiceMice, Inbred C57BLVascular Endothelial Growth Factor Avascular endothelial growth factor A, mousechoroidal neovascularizationendothelial cellsoxygen-induced ischemic retinopathyPDGFpericytesretinal vasculatureVEGFA

Identifiers

PMID41002438
PMCPMC12469127

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.