ReviewScience progress
Complement and local ocular inflammatory response: Chronic immune factors in myopia.
Review in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Cellular Biological Basis and Novel Breakthroughs in the Pathogenesis of Myopia - A Narrative Review.International journal of general medicine · 2026Review
- Revisiting pathologic myopia: imaging evidence of an inflammatory component in the pathogenesis of myopic degeneration.Frontiers in medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myopia has emerged as a globally pervasive visual disorder, with its incidence rising steadily, particularly among children and adolescents, posing a significant threat to ocular health. Recent research underscores a strong link between chronic inflammatory processes and both the onset and progression of myopia. As a cornerstone of the innate immune system, the complement cascade plays a pivotal role in mediating ocular inflammatory diseases associated with high myopia, including macular degeneration, glaucoma, allergic conjunctivitis, uveitis, and scleritis. Accumulating evidence indicates that complement activation contributes to myopia pathogenesis by orchestrating local inflammatory responses within the eye. This article is a narrative review that synthesizes current evidence on complement-myopia interactions, with a focus on the underlying biological mechanisms and their potential as therapeutic targets for both preventing and managing myopia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.