Evidence map›Paper›PMID 41002100›Full record

ReviewCNS oncology2025

Multiple brain lesions in a patient with relapsed hairy cell leukemia: a case report and review of the literature.

Katell Le Dû, Jacques Delaunay, Maud Voldoire, Thomas Cuvier, Pierre-Yves Renard, Benoît Quilichini, Eric Wafflart, Julien Dubreuil, Sophie Sadot-Lebouvier

Abstract readCase ReportsReview
In one paragraph

Review in CNS oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Katell Le DûDepartment of Hematology, Hôpital Privé Le Confluent, Nantes, France.ORCID 0000-0003-4371-2668
Jacques DelaunayDepartment of Hematology, Hôpital Privé Le Confluent, Nantes, France.ORCID 0009-0007-6186-4389
Maud VoldoireDepartment of Hematology, Hôpital Privé Le Confluent, Nantes, France.ORCID 0009-0006-3351-4309
Thomas CuvierDepartment of Onco-hematology, Hôpital Privé Le Confluent, Nantes, France.ORCID 0009-0003-4666-2026
Pierre-Yves RenardDepartment of Pharmacy, Hôpital Privé Le Confluent, Nantes, France.ORCID 0009-0004-3003-3038
Benoît QuilichiniDepartment of Molecular Biology, Eurofins Biomnis, Lyon, France.ORCID 0009-0009-1190-202X
Eric WafflartDepartment of Radiology, Hôpital Privé Le Confluent, Nantes, France.ORCID 0009-0009-6901-4869
Julien DubreuilDepartment of Nuclear Medicine, Hôpital Privé Le Confluent, Nantes, France.ORCID 0000-0003-2735-9534
Sophie Sadot-LebouvierDepartment of Hematology, Hôpital Privé Le Confluent, Nantes, France.ORCID 0009-0003-4255-4116

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral lesions are rare in hairy cell leukemia (HCL), and its incidence remains to be determined. Identifying the cause can be challenging. In this report, we present a case of brain lesions occurring several years after diagnosis. A 76-year-old male patient presented to the Emergency Department with confusion. He had been diagnosed with HCL in 1999 and had received five lines of treatment. Cerebral imaging revealed multiple nodular lesions, with edema and a hemorrhagic appearance. Cerebrospinal fluid tests were negative. The tumor origin was retained due to concomitant relapse (blood, lymph nodes). Despite the partial efficacy of rituximab-cladribine treatment, the patient died of

Indexed as

BrainBrain NeoplasmsLeukemia, Hairy CellNeoplasm Recurrence, LocalAgedFatal OutcomeHumansMaleBRAF inhibitorsBrain imagingBTK (Bruton Tyrosine Kinase) inhibitorscase reportcirculating tumor DNAhairy cell leukemianodular hemorrhagic lesions

Identifiers

PMID41002100
PMCPMC12477879

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.