ArticleThe Journal of clinical investigation1979
Mechanisms of killing of newborn larvae of Trichinella spiralis by neutrophils and eosinophils. Killing by generators of hydrogen peroxide in vitro.
Article in The Journal of clinical investigation, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Modulatory Effect of Beneficial Enterococci and Their Enterocins on the Blood Phagocytes in Murine Experimental Trichinellosis.Life (Basel, Switzerland) · 2023Article
- Serine protease inhibitor derived fromFrontiers in cellular and infection microbiology · 2022Article
- Article
- A Trypsin-Sensitive Proteoglycan from the Tapeworm Hymenolepis diminuta Inhibits Murine Neutrophil Chemotaxis in vitro by Suppressing p38 MAP Kinase Activation.Journal of innate immunity · 2019Article
- A Proteomic Investigation of Hepatic Resistance to Ascaris in a Murine Model.PLoS neglected tropical diseases · 2016Article
- Enzymatic antioxidant systems in helminth parasites.Parasitology research · 2009Review
- New aspects of human trichinellosis: the impact of new Trichinella species.Postgraduate medical journal · 2002Review
- Excretory-secretory product of Paragonimus westermani newly excysted metacercariae inhibits superoxide production of granulocytes stimulated with IgG.The Korean journal of parasitology · 2000Article
- Trapping and immobilization of Nippostrongylus brasiliensis larvae at the site of inoculation in primary infections of interleukin-5 transgenic mice.Infection and immunity · 1999Article
- Helminthotoxic responses of intestinal eosinophils to Trichinella spiralis newborn larvae.Infection and immunity · 1991Article
- Morphological investigations on the pathology of Dictyocaulus viviparus infections in cattle.Parasitology research · 1991Article
- Oxidative requirement for degranulation of human peripheral blood eosinophils.Infection and immunity · 1988Article
- Eosinophils as effector cells in immunity and hypersensitivity disorders.Clinical and experimental immunology · 1985Review
- Eosinophil adherence to infective larvae of Trichinella spiralis: quantification and modulation.Immunology · 1985Article
- Specific granules of rat eosinophils contain peroxisomal acyl-CoA oxidase: possible involvement in production of H2O2.The Histochemical journal · 1984Article
- Complement-dependent killing of Nippostrongylus brasiliensis infective larvae by rat alveolar macrophages.Clinical and experimental immunology · 1984Article
- Immunocytochemical localization of two peroxisomal enzymes of lipid beta-oxidation in specific granules of rat eosinophils.Histochemistry · 1983Article
- Rat mononuclear cells and neutrophils are more effective than eosinophils in antibody-mediated stage-specific killing of Trichinella spiralis in vitro.Zeitschrift fur Parasitenkunde (Berlin, Germany) · 1983Article
- Oxidant-mediated damage of Leishmania donovani promastigotes.Infection and immunity · 1982Article
- Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.The Journal of clinical investigation · 1981Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eosinophil and/or neutrophil leukocytes appear to have important roles in host defense against invasive, migratory helminth infestations, but the mechanisms of larval killing by leukocytes are uncertain. This study examines killing of newborn (migratory phase) larvae of Trichinella spiralis during incubation with granule preparations of human eosinophils or neutrophils and generators of hydrogen peroxide (glucose-glucose oxidase) (G-GO) or superoxide and hydrogen peroxide (xanthine-xanthine oxidase). Larvae were killed by either hydrogen peroxide-generating system in a concentration-dependent manner. Direct enumeration of surviving larvae after incubation in microtiter wells containing the appropriate reagents was used in assess larval killing. Verification of the microplate assay was demonstrated by complete loss of larval ability to incorporate [(3)H]deoxyglucose and loss of infectivity after incubation in comparable concentrations of G-GO. Larvae were highly sensitive to oxidative products; significant killing occurred after incubation with 0.12 mU glucose oxidase and complete killing occurred with 0.5 mU. Comparable killing of bacteria required over 60 mU glucose oxidase. At 5 mU glucose oxidase, killing was complete after 6 h of incubation. Killing by G-GO was inhibited by catalase but not by boiled catalase or superoxide dismutase and was enhanced by azide. Addition of peroxidase in granule pellet preparations of eosinophils or neutrophils did not enhance killing by G-GO. These data indicate a remarkable susceptibility of newborn larvae of T. spiralis to the hydrogen peroxide generated by neutrophil and eosinophil leukocytes.
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