ArticleAngewandte Chemie (International ed. in English)2025
Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production.
Article in Angewandte Chemie (International ed. in English), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Catalytic Amyloids: Turning Fibrils Into Biocatalysts.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Review
- Structure-activity relationships in catalytic amyloids.Journal of inorganic biochemistry · 2026Article
- Amyloid Peptide Nanofibrils Promote Efficient Neurotransmitter Oxidation and Serve as Scaffolds for Melanin Production.Angewandte Chemie (International ed. in English) · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
We have shown that de novo designed peptides self-assemble in the presence of copper to create supramolecular assemblies capable of carrying out the oxidation of a range of neurotransmitters in the presence of dioxygen and hydrogen peroxide with high efficiency and in a sequence dependent manner. Moreover, these catalytic peptide assemblies are capable of templating melanin production. Guided by the structure activity relationships identified using the model systems we discovered that peptide assemblies formed by fragments of human carbonic anhydrase VII found in the brain also promote neurotransmitter degradation, supporting its role in neurodegenerative disease. Altogether, our results further support the role of metal-promoted catalysis in neurodegenerative disease and will facilitate development of new catalyst nanomaterials capable of promoting oxidative transformation.
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Registered trials
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