Evidence map›Paper›PMID 41001899›Full record

SynthesisCancer medicine2025

Association Between Metabolic Syndrome and Its Components and the Risk of Head and Neck Cancer: A Systematic Review and Meta-Analysis.

Qingling Wang, Shiduo Guo, Ruizhe Huang, Zhenju Xu, Dapeng Liang, Yichuan Huang, Yubo Sun, Weiqi Yang, Liwei Jiang

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cancer medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qingling WangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Shiduo GuoDepartment of Hepatobiliary Surgery, Qingdao Jimo People's Hospital, Qingdao, Shandong, China.
Ruizhe HuangThe First Clinical College, Changsha Medical University, Changsha, China.ORCID https://orcid.org/0009-0005-6686-3452
Zhenju XuDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Dapeng LiangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yichuan HuangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Yubo SunDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Weiqi YangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Liwei JiangDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.ORCID https://orcid.org/0009-0001-4163-8970

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe relationship between metabolic syndrome (MetS) and head and neck cancer (HNC) remains controversial. The present meta-analysis evaluated the association between MetS and the risk of developing HNC.

methodsA literature search was conducted across various databases, including Embase, Cochrane, PubMed, and Web of Science, to identify studies investigating the relationship between MetS and the risk of HNC.

resultsTwelve studies involving 55,692 participants were included. We found limited evidence of an association between MetS and the risk of developing HNC (RR = 1.1, 95% CI: 1.0-1.2, p = 0.07, I

conclusionsIn conclusion, our meta-analysis found little evidence of an association between MetS and the risk of developing HNC. However, high LDL and total cholesterol levels may be associated with a reduced risk of HNC, while being underweight may be associated with increased risk of HNC. These results need to be interpreted with caution due to the limited number of supporting studies.

Indexed as

Head and Neck NeoplasmsMetabolic SyndromeHumansRisk Factorshead and neck cancermeta‐analysismetabolic syndromerelative risksystematic review

Identifiers

PMID41001899
PMCPMC12464883

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.