Evidence map›Paper›PMID 41001805›Full record

ArticleAllergy2025

Comparison of Allergic Rhinitis Treatments on Patient Satisfaction: A MASK-air and EAACI Methodological Committee Report.

Bernardo Sousa-Pinto, Rafael José Vieira, Antonio Bognanni, Matteo Martini, Michal Ordak, Giovanni Paoletti, Sara Gil-Mata, Rita Amaral, Anna Bedbrook, Patrizia Bonadonna and 36 more

Abstract readComparative Study
In one paragraph

Article in Allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Guideline
  2. Guideline
  3. Comparison of Allergic Rhinitis Treatments on Utilities and Quality of Life: A MASK-air Study.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026
    Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors.

Bernardo Sousa-PintoMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Rafael José VieiraMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0003-1834-3055
Antonio BognanniDepartment of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.ORCID https://orcid.org/0000-0003-0128-903X
Matteo MartiniAllergy Unit, Department of Internal Medicine, University Hospital AOU delle Marche, Ancona, Italy.ORCID https://orcid.org/0000-0001-9873-9695
Michal OrdakDepartment of Pharmacotherapy and Pharmaceutical Care, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland.ORCID https://orcid.org/0000-0001-5652-4397
Giovanni PaolettiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.ORCID https://orcid.org/0000-0003-3953-9225
Sara Gil-MataMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Rita AmaralMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.ORCID https://orcid.org/0000-0002-0233-830X
Anna BedbrookARIA, Montpellier, France.
Patrizia BonadonnaAllergy Unit and Asthma Center, Verona University Hospital, Verona, Italy.
Luisa BrussinoDepartment of Medical Sciences, University of Torino, Torino, Italy.
G Walter CanonicaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy.ORCID https://orcid.org/0000-0001-8467-2557
João Coutinho-AlmeidaMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Álvaro A CruzFundaçao ProAR, and (Faculdade de Medicina da) Universidade Federal da Bahia, Salvador, Bahia, Brazil.ORCID https://orcid.org/0000-0002-7403-3871
Wienczyslawa CzarlewskiARIA, Montpellier, France.
Mark DykewiczSection of Allergy and Immunology, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
Mattia GiovanniniAllergy Unit, Meyer Children's Hospital IRCCS, Florence, Italy.ORCID https://orcid.org/0000-0001-9568-6882
Bilun GemiciogluDepartment of Pulmonary Diseases, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
Juan Carlos IvancevichServicio de Alergia e Immunologia, Clinica Santa Isabel, Buenos Aires, Argentina.
Ludger KlimekDepartment of Otolaryngology, Head and Neck Surgery, Universitätsmedizin Mainz, Mainz, Germany.ORCID https://orcid.org/0000-0002-2455-0192
Violeta KvedarieneInstitute of Clinical Medicine, Clinic of Chest Diseases and Allergology, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Desiree E Larenas-LinnemannCenter of Excellence in Asthma and Allergy, Médica Sur Clinical Foundation and Hospital, México City, Mexico.
Manuel Marques-CruzMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
André MoreiraEPIUnit-Institute of Public Health, University of Porto, and Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal.
Marek NiedoszytkoDepartment of Allergology, Medical University of Gdansk, Gdansk, Poland.ORCID https://orcid.org/0000-0003-1089-1911
Ana Margarida PereiraMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Nikolaos G PapadopoulosAllergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0002-4448-3468
Nhan Pham-ThiEcole Polytechnique de Palaiseau, Palaiseau, France.
Frederico S RegateiroAllergy and Clinical Immunology Department, Hospitais da Universidade de Coimbra, Unidade Local de Saúde de Coimbra, Coimbra, Portugal.
Sanna K Toppila-SalmiDepartment of Otorhinolaryngology, University of Eastern Finland and the North Savo Wellbeing Services County, Kuopio, Finland.ORCID https://orcid.org/0000-0003-0890-6686
Boleslaw SamolinskiDepartment of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Warsaw, Poland.
Joaquin SastreAllergy Service, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, CIBERES-ISCIII, Madrid, Spain.
Luís Taborda-BarataRISE-Health, Faculty of Health Sciences, and UBIAir-Clinical & Experimental Lung Centre, University of Beira Interior, Covilhã, Portugal.
Tuuli ThomanderMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Ilgım Vardaloğlu KoyuncuDepartment of Pulmonary Diseases, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Turkey.
Arunas ValiulisClinic of Asthma, Allergy and Chronic Lung Diseases, Vilnius, Lithuania.
Leticia de Las VecillasDepartment of Allergy, Hospital La Paz Institute for Health Research (IdiPAZ), Madrid, Spain.ORCID https://orcid.org/0000-0003-4969-5678
Maria Teresa VenturaUniversity of Bari Medical School, Bari, Italy.
Jolanta Walusiak-SkorupaDepartment of Occupational Diseases and Environmental Health, Nofer Institute of Occupational Medicine, Lodz, Poland.
Yi-Kui XiangInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3432-6837
Oliver PfaarSection of Rhinology and Allergy, Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps-Universität Marburg, Marburg, Germany.ORCID https://orcid.org/0000-0003-4374-9639
João A FonsecaMEDCIDS-Department of Community Medicine, Information and Health Decision Sciences, Faculty of Medicine, University of Porto, Porto, Portugal.
Torsten ZuberbierInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-1466-8875
Holger J SchünemannDepartment of Health Research Methods, Evidence, and Impact & Department of Medicine, Evidence in Allergy Group, McMaster University, Hamilton, Ontario, Canada.
Danilo di BonaDepartment of Medical and Surgical Science, University of Foggia, Foggia, Italy.
Jean BousquetInstitute of Allergology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-4061-4766

Funding

European Academy of Allergy and Clinical ImmunologyMASK-air SAS
6 · The paper itself

Abstract

introductionSatisfaction with treatments may affect medication adherence and use patterns, including the use of co-medication. We aimed to compare different medications for allergic rhinitis (AR) on (i) patients' satisfaction and (ii) co-medication use frequency.

methodsWe assessed data from the mHealth app MASK-air. We evaluated days on which users with self-reported AR had used-alone or in co-medication-intranasal corticosteroids (INCS), intranasal antihistamines (INAH), fixed combinations of INAH+INCS, or oral antihistamines (OAH). We built multivariable regression models to compare these different AR medication classes (as well as individual medications) on their (i) treatment satisfaction levels (measured using a specific daily visual analogue scale ['VAS satisfaction']) and (ii) odds of being used in co-medication.

resultsWe assessed 28,177 days reported by 1691 MASK-air users. For all medication classes, co-medication usage was associated with lower treatment satisfaction. When used in monotherapy, OAH were associated with lower VAS satisfaction than INCS (-1.7 points; 95% CI = -2.7; -0.7) or INAH+INCS (-2.1 points; 95% CI = -3.5; -0.7). INCS displayed higher odds of being used in co-medication than OAH (OR = 1.3; 95% CI = 1.0; 1.6) or INAH+INCS (OR = 1.3; 95% CI = 0.8; 1.8). When comparing individual intranasal medications, fluticasone furoate and fluticasone propionate tended to be more frequently used in co-medication. Among individual OAH, desloratadine and rupatadine were associated with higher satisfaction, while fexofenadine was more frequently used in co-medication.

conclusionUsing patient-reported data, we evaluated different medication classes and treatments in terms of satisfaction and co-medication frequency. These results provide key insights into the acceptability of AR treatments and will contribute to future treatment guidelines.

Indexed as

Anti-Allergic AgentsPatient SatisfactionRhinitis, AllergicAdministration, IntranasalAdolescentAdrenal Cortex HormonesAdultFemaleHistamine AntagonistsHumansMaleMiddle AgedTreatment OutcomeYoung AdultAdrenal Cortex HormonesAnti-Allergic AgentsHistamine Antagonists

Identifiers

PMID41001805
PMCPMC12666759

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.