Evidence map›Paper›PMID 41001759›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

Immunoregulatory Roles of Tumor-Originated Pericytes Identified by Single-Cell Analysis in Glioblastoma.

Cuiying Chu, Fangzhen Li, Zhiwen Zhang, Qiuhong Zhu, Hong Yan, Mengdan Cheng, Huipeng Wang, Lei Cheng, Zhe Zhang, Xingjiang Yu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Cuiying ChuDepartment of Pathology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Fangzhen LiDepartment of Pathology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Zhiwen ZhangDepartment of Pathology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Qiuhong ZhuDepartment of Pathology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Hong YanIntelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Mengdan ChengIntelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Huipeng WangInstitute of Children's Health, Henan Academy of Medical Sciences, Zhengzhou, 451162, China.
Lei ChengDepartment of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, 266000, China.
Zhe ZhangBasic Medical College, Qingdao University, Qingdao, 266073, China.
Xingjiang YuDepartment of Histology and Embryology, School of Basic Medicine, Tongji Medical College, Hubei Key Laboratory of Drug Target Research and Pharmacodynamic Evaluation, Huazhong University of Science and Technology, Wuhan, 430030, China.
Jianghong ManNanhu Laboratory, National Center of Biomedical Analysis, Beijing, 100850, China.
Wei WangIntelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Dongxue LiDepartment of Neurosurgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Xiu-Wu BianIntelligent Pathology Institute, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Hai-Bo WuDepartment of Pathology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.
Aili ZhangResearch Center for Translational Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Wenchao ZhouDepartment of Pathology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230036, China.ORCID https://orcid.org/0000-0002-6650-1831

Funding

National Key Research and Development Program of China 2024ZD0525100National Natural Science Foundation of China 82173354National Natural Science Foundation of China 82373087National Natural Science Foundation of China 82472916National Natural Science Foundation of China 82573320Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM 2023IHM01042Research Funds of Centre for Leading Medicine and Advanced Technologies of IHM 2023IHM01043
6 · The paper itself

Abstract

Pericytes as critical vascular support cells not only keep the integrity of blood-brain barrier but also play profound roles in brain tumors. Yet the origin and functional heterogeneity of pericytes in the most common malignant brain tumor glioblastoma (GBM) remain unclear. Here, single-cell RNA-sequencing (scRNA-seq) is performed on CD146

Indexed as

Brain NeoplasmsGlioblastomaPericytesAnimalsHumansHyaluronan ReceptorsMiceSingle-Cell AnalysisHyaluronan Receptorsglioblastomamacrophagepericytetumor immunologyvasculature

Identifiers

PMID41001759
PMCPMC12713092

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.