ReviewFrontiers in endocrinology2025
Complementary efficacy and molecular insights of
Review in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Review
- Molecular mechanisms and structure-activity relationships of natural polysaccharides in ameliorating type 2 diabetes mellitus: a comprehensive review.Frontiers in nutrition · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: T2DM is a global health challenge characterized by insulin resistance and impaired glucose metabolism. Natural products, such as polysaccharides from medicinal plants, are increasingly explored for their potential in managing T2DM with fewer side effects compared to conventional drugs. Aim: This review aims to comprehensively evaluate the effects of Introduction: In recent years, numerous scientific studies have demonstrated that Methods: A comprehensive literature search was conducted across electronic databases including PubMed, Web of Science, Wanfang Database, and China National Knowledge Infrastructure (CNKI). The search encompassed publications from June 2010 to June 2025, representing a 15-year period. Titles and abstracts were systematically screened for relevance, after which full-text articles meeting the inclusion criteria within this timeframe were selected for analysis. Discussion: Current evidence indicates that PRP can ameliorate T2DM alongside improving glucose and lipid profiles; this effect is predominantly linked to its modulation of the PI3K/AKT signaling pathway. Furthermore, its lipid-lowering properties are associated with regulation of gut microbiota, enhancement of intestinal barrier function, promotion of short-chain fatty acids (SCFAs) production, activation of G Protein-Coupled Receptors 41 and 43 (GPCR41 and 43), as well as inhibition of the TLR4/MyD88/NF-κB signaling cascade. Conclusion:
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.