Evidence map›Paper›PMID 41001656›Full record

ArticleJACS Au2025

Modular Synthesis of Substituted Lactams via a Deoxygenative Photochemical Alkylation-Cyclization Cascade of Secondary Amides in Flow.

Damiano Diprima, Thomas Terp Paulsen, Antonio Pulcinella, Stefano Bonciolini, Alexis L Gabbey, Robin Stuhr, Thomas Bjørnskov Poulsen, Timothy Noël

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Damiano DiprimaFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.
Thomas Terp PaulsenFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.
Antonio PulcinellaFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.
Stefano BoncioliniFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.
Alexis L GabbeyFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.ORCID https://orcid.org/0000-0003-2544-636X
Robin StuhrFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.
Thomas Bjørnskov PoulsenDepartment of Chemistry, Aarhus University, Langelandsgade 140, 8000 Aarhus C, Denmark.ORCID https://orcid.org/0000-0002-0763-9996
Timothy NoëlFlow Chemistry Group, Van't Hoff Institute for Molecular Sciences(HIMS), University of Amsterdam, Science Park 904, Amsterdam 1098 XH, The Netherlands.ORCID https://orcid.org/0000-0002-3107-6927

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γ-Lactams are crucial scaffolds in many bioactive compounds and pharmaceutical agents, yet their synthesis featuring diverse γ- and

Indexed as

flow cascadeflow chemistrylactam synthesisphotochemical alkylationphotochemistrysecondary amide activation

Identifiers

PMID41001656
PMCPMC12458026

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.