ArticleJACS Au2025
Lipid-Oxidative Enzymes and Fenton-Like Reactions Are Synergistic in Promoting Membrane Lipid Peroxidation.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.Journal of enzyme inhibition and medicinal chemistry · 2026Review
- Iron Supplementation and Neurodevelopmental Outcomes in Infancy and Early Childhood: A Review.Children (Basel, Switzerland) · 2026Review
- Membrane curvature enhances oxidation within lipid bilayers in a composition-dependent manner.Biophysical journal · 2026Article
- Mechanism analysis of uniconazole pretreatment improving waterlogging tolerance of different genotypes of Brassica napus L.BMC plant biology · 2026Article
- Effects of hyperbaric air exposure with oxygen breathing during decompression on the exhaled volatile organic compounds.Frontiers in physiology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Lipid peroxidation (LPO) of cellular membranes is a near-universal indicator of aging and disease, yet the mechanistic link between the LPO and disease remains elusive. In this study, we demonstrate that efficient LPO in model membranes is accomplished through synergy between selective enzymatic oxidation by lipoxygenase (LOX) and nonspecific oxidation by reactive oxygen species (ROS). Through fluorescence-based oxidation kinetic measurements, we show that soluble ROS alone fails to induce significant oxidation under physiologically relevant conditions. However, enzymatic oxidation enhances the ROS-driven LPO by altering membrane permeability. Strikingly, this process drives the macroscopic clustering of the membrane-bound protein KRAS on giant unilamellar vesicles (GUVs), revealing potential functional consequences. If this mechanism extends to living cells, it could reshape our understanding of oxidative stress in disease. Our findings represent an essential step toward advancing an integrated understanding of oxidative membrane biology, encompassing both enzymatic oxidation and oxidation by ROS.
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Registered trials
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