Evidence map›Paper›PMID 41001644›Full record

ArticleJACS Au2025

Microneedle-Based DNA Tension Gauge Tethers Enable In Vivo Monitoring of Cell Mechanics during Skin Tissue Regeneration.

Xiaofei Ma, Yuanbin Guo, Haotian Li, Chen Zhao, Xuran Dai, Mo Ma, Pinyi Ma, Daqian Song, Yongxi Zhao, Feng Chen and 1 more

Abstract read
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In one paragraph

Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaofei MaCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, P. R. China.
Yuanbin GuoInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
Haotian LiInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.
Chen ZhaoCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, P. R. China.
Xuran DaiCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, P. R. China.
Mo MaCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, P. R. China.
Pinyi MaCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, P. R. China.ORCID https://orcid.org/0000-0002-3230-4928
Daqian SongCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, P. R. China.ORCID https://orcid.org/0000-0002-4866-1292
Yongxi ZhaoInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.ORCID https://orcid.org/0000-0002-1796-7651
Feng ChenInstitute of Analytical Chemistry and Instrument for Life Science, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi 710049, P. R. China.ORCID https://orcid.org/0000-0003-0188-6256
Ying SunCollege of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, P. R. China.ORCID https://orcid.org/0000-0002-6820-3184

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The mechanical force exerted by dermal fibroblasts is crucial for promoting cutaneous tissue regeneration and wound healing. However, the implantation of a force interface in vivo or within tissue has become a new challenge in measuring mechanical force. Here, we report a microneedle patch with DNA tension gauge tethers (ME-TGT patch) to monitor the mechanical force of dermal fibroblasts in mice. Microneedles served as the force and electrode interface. When the integrin of the fibroblast membrane is successfully recognized by the integrin ligand (cRGDfk) in the tension probe, the duplex splits irreversibly by cellular mechanical force. The conformation rearrangement driven by a mechanical force can be converted into electrochemical signals. The ME-TGT patch can be used for verification of approximately 12 piconewtons (pN) of mechanical force exerted by fibroblasts in vitro and in vivo. Moreover, we used the ME-TGT patch to monitor cell mechanics during wound healing in skin tissue and found fluctuation (rising first and then falling in the process of 0-14 days) in mice. The ME-TGT patch allowed for monitoring mechanical force on fibroblasts in vivo and provided a novel tool for further research into mechanical mechanisms in tissue regeneration.

Indexed as

dermal fibroblastsDNA tension probesmechanical forceMicroneedletissue regeneration

Identifiers

PMID41001644
PMCPMC12458006

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.