ArticleJACS Au2025
Electrochemical Investigation of Post-Translational Modification-Modulated Biomolecular Liquid-Liquid Phase Separation.
Article in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Multiaxial Biophysical Control of Oncogenic Phase Separation by Indoleamines: A Proof-of-Concept Synthesis of Landscape-Level Regulation.Journal of pineal research · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-translational modification (PTM) plays a key role in the regulation of liquid-liquid phase separation (LLPS), which participates in cell behaviors and pathological processes. Quantitative analysis of PTM-regulated LLPS is therefore essential for understanding cellular processes and discovering new disease targets. However, the membrane-free structure, dynamic characteristics, and distinct chemical microenvironment of biomolecular condensates pose challenges to traditional methods. In this contribution, an electrochemical method is proposed to analyze PTM-regulated LLPS for the first time by exploring its effect on electrochemical species. By taking dephosphorylation as a model, we demonstrate that the degree of LLPS initiated by dephosphorylation can be quantitatively assessed. Importantly, this label-free method does not require probe immobilization or signal tagging, making it easily extendable to various PTM-involved LLPS processes. Overall, this work provides a highly sensitive, simplified, and universal approach for the quantitative study of LLPS, with broad potential applications in physiological and pathological research studies.
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