ReviewJACS Au2025
Emerging Research on Gene Delivery to the Nucleus via DNA Origami.
Review in JACS Au, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From Blueprint to Breakthrough: How Far Can We Fold DNA Origami for Nano-Enabled Technologies?JACS Au · 2026Review
- Payload-Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure-Function Relationships.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Structural DNA nanotechnology, a research field in which scientists use DNA as the primary material to make designer nanostructures, has experienced rapid growth in the past few decades. The continuous development of the field has produced a rich repository of impressive, complex nanostructures for applications in materials science, biological research, and therapeutics. The unprecedented programmability of DNA nanostructures, particularly DNA origami, combined with the biocompatibility and rich functionality of DNA molecules make them attractive candidates for building nanocarriers for cellular delivery. While the initial research toward this direction focused on the delivery of small molecule drugs and short nucleic acids, emerging efforts in the last two years have expanded to gene delivery by leveraging the capacity of DNA origami to fold gene sequences into compact structures amenable for cell delivery. Here, we review this exciting research direction and provide our perspective on the challenges and opportunities in this field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.